Human Gene MRPL1 (ENST00000315567.13) from GENCODE V44
Description: Homo sapiens mitochondrial ribosomal protein L1 (MRPL1), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_020236) RefSeq Summary (NM_020236): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000315567.13 Gencode Gene: ENSG00000169288.18 Transcript (Including UTRs) Position: hg38 chr4:77,862,830-77,952,785 Size: 89,956 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr4:77,862,849-77,952,607 Size: 89,759 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYD6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HQ447344 - Synthetic construct Homo sapiens clone IMAGE:100070665; CCSB007386_01 mitochondrial ribosomal protein L1 (MRPL1) gene, encodes complete protein. KJ903113 - Synthetic construct Homo sapiens clone ccsbBroadEn_12507 MRPL1 gene, encodes complete protein. KJ904857 - Synthetic construct Homo sapiens clone ccsbBroadEn_14251 MRPL1 gene, encodes complete protein. AF212225 - Homo sapiens BM022 mRNA, complete cds. BC017765 - Homo sapiens mitochondrial ribosomal protein L1, mRNA (cDNA clone IMAGE:4284885), partial cds. BC014356 - Homo sapiens mitochondrial ribosomal protein L1, mRNA (cDNA clone MGC:24210 IMAGE:3686618), complete cds. AK315600 - Homo sapiens cDNA, FLJ96680. BC015109 - Homo sapiens mitochondrial ribosomal protein L1, mRNA (cDNA clone MGC:22872 IMAGE:4044993), complete cds. BC032595 - Homo sapiens mitochondrial ribosomal protein L1, mRNA (cDNA clone MGC:45037 IMAGE:5527878), complete cds. AB049474 - Homo sapiens MRPL1 mRNA for mitochondrial ribosomal protein L1 (L1mt), complete cds. CU677215 - Synthetic construct Homo sapiens gateway clone IMAGE:100018782 5' read MRPL1 mRNA. CR457191 - Homo sapiens full open reading frame cDNA clone RZPDo834D1212D for gene MRPL1, mitochondrial ribosomal protein L1; complete cds, incl. stopcodon. AK024791 - Homo sapiens cDNA: FLJ21138 fis, clone CAS07525. JD236715 - Sequence 217739 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BYD6 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins