The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P29803
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GO:0016491 oxidoreductase activity GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0034604 pyruvate dehydrogenase (NAD+) activity
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006086 acetyl-CoA biosynthetic process from pyruvate GO:0006090 pyruvate metabolic process GO:0006099 tricarboxylic acid cycle GO:0008152 metabolic process GO:0055114 oxidation-reduction process
BioCyc Knowledge Library PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle PYRUVDEHYD-PWY - pyruvate decarboxylation to acetyl CoA
Reactome (by CSHL, EBI, and GO)
Protein P29803 (Reactome details) participates in the following event(s):
R-HSA-203946 PDK isoforms phosphorylate lipo-PDH R-HSA-204169 PDP dephosphorylates p-lipo-PDH R-HSA-6792572 LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs R-HSA-71397 lipo-PDH decarboxylates PYR to Ac-CoA R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-5362517 Signaling by Retinoic Acid R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-70268 Pyruvate metabolism R-HSA-9006931 Signaling by Nuclear Receptors R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-162582 Signal Transduction R-HSA-1430728 Metabolism R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport