Human Gene ADH4 (ENST00000265512.12) from GENCODE V44
Description: Homo sapiens alcohol dehydrogenase 4 (class II), pi polypeptide (ADH4), transcript variant 3, mRNA. (from RefSeq NM_000670) RefSeq Summary (NM_000670): This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000265512.12 Gencode Gene: ENSG00000198099.10 Transcript (Including UTRs) Position: hg38 chr4:99,123,658-99,144,297 Size: 20,640 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr4:99,124,442-99,144,222 Size: 19,781 Coding Exon Count: 9
ID:ADH4_HUMAN DESCRIPTION: RecName: Full=Alcohol dehydrogenase 4; EC=1.1.1.1; AltName: Full=Alcohol dehydrogenase class II pi chain; CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone + NADH. COFACTOR: Binds 2 zinc ions per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08319
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.