Human Gene FBXL7 (ENST00000504595.2) from GENCODE V44
Description: Homo sapiens F-box and leucine rich repeat protein 7 (FBXL7), transcript variant 1, mRNA. (from RefSeq NM_012304) RefSeq Summary (NM_012304): This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000504595.2 Gencode Gene: ENSG00000183580.10 Transcript (Including UTRs) Position: hg38 chr5:15,500,180-15,939,793 Size: 439,614 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr5:15,500,677-15,937,186 Size: 436,510 Coding Exon Count: 4
ID:FBXL7_HUMAN DESCRIPTION: RecName: Full=F-box/LRR-repeat protein 7; AltName: Full=F-box and leucine-rich repeat protein 7; AltName: Full=F-box protein FBL6/FBL7; FUNCTION: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome (By similarity). Note=Localizes to the centrosome during spindle formation (By similarity). SIMILARITY: Belongs to the FBXL7 family. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 11 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=BAA74863.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UJT9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
