Human Gene AGXT2 (ENST00000231420.11) from GENCODE V44
Description: Homo sapiens alanine--glyoxylate aminotransferase 2 (AGXT2), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_031900) RefSeq Summary (NM_031900): The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Gencode Transcript: ENST00000231420.11 Gencode Gene: ENSG00000113492.14 Transcript (Including UTRs) Position: hg38 chr5:34,998,102-35,047,949 Size: 49,848 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr5:34,998,719-35,047,892 Size: 49,174 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYV1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0009436 glyoxylate catabolic process GO:0019265 glycine biosynthetic process, by transamination of glyoxylate GO:0019481 L-alanine catabolic process, by transamination GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0046487 glyoxylate metabolic process
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