Human Gene FST (ENST00000256759.8) from GENCODE V44
Description: Homo sapiens follistatin (FST), transcript variant FST344, mRNA. (from RefSeq NM_013409) RefSeq Summary (NM_013409): Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000256759.8 Gencode Gene: ENSG00000134363.12 Transcript (Including UTRs) Position: hg38 chr5:53,480,629-53,487,134 Size: 6,506 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr5:53,480,792-53,486,033 Size: 5,242 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19883
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002244 hematopoietic progenitor cell differentiation GO:0007165 signal transduction GO:0032926 negative regulation of activin receptor signaling pathway GO:0051798 positive regulation of hair follicle development
Cellular Component: GO:0005576 extracellular region
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