Human Gene ADAMTS19 (ENST00000274487.9) from GENCODE V44
  Description: Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 19 (ADAMTS19), mRNA. (from RefSeq NM_133638)
RefSeq Summary (NM_133638): This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000274487.9
Gencode Gene: ENSG00000145808.10
Transcript (Including UTRs)
   Position: hg38 chr5:129,460,298-129,738,683 Size: 278,386 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg38 chr5:129,460,392-129,737,218 Size: 276,827 Coding Exon Count: 23 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:129,460,298-129,738,683)mRNA (may differ from genome)Protein (1213 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADAMTS19
Diseases sorted by gene-association score: peters-plus syndrome (2), premature ovarian failure 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.90 RPKM in Uterus
Total median expression: 17.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.2094-0.577 Picture PostScript Text
3' UTR -319.001465-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  BC156492 - Synthetic construct Homo sapiens clone IMAGE:100063096, MGC:190688 ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19) mRNA, encodes complete protein.
AJ311904 - Homo sapiens mRNA for ADAMTS19 protein (ADAMTS19 gene).
AK128729 - Homo sapiens cDNA FLJ46897 fis, clone UTERU3021850, weakly similar to ADAM-TS 7 precursor (EC 3.4.24.-).
AK122622 - Homo sapiens cDNA FLJ16042 fis, clone BRAMY2021498, highly similar to ADAMTS-19 precursor (EC 3.4.24.-).

-  Other Names for This Gene
  Alternate Gene Symbols: A0A1X7SBR9, ENST00000274487.1, ENST00000274487.2, ENST00000274487.3, ENST00000274487.4, ENST00000274487.5, ENST00000274487.6, ENST00000274487.7, ENST00000274487.8, NM_133638, uc003kvb.1, uc003kvb.2, uc003kvb.3, uc003kvb.4
UCSC ID: ENST00000274487.9
RefSeq Accession: NM_133638
CCDS: CCDS4146.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.