ID:PK2L2_HUMAN DESCRIPTION: RecName: Full=Polycystic kidney disease 2-like 2 protein; AltName: Full=Polycystin-2L2; AltName: Full=Polycystin-L2; FUNCTION: May function as a subunit of a cation channel and play a role in fertilization. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: According to PubMed:10602361, expressed only in testis. According to PubMed:10756092, expressed also in brain and kidney. Isoform 2 is found only in transformed lymphoblasts. Isoform 3 is found in all tissues tested. SIMILARITY: Belongs to the polycystin family. SEQUENCE CAUTION: Sequence=AAD46478.1; Type=Frameshift; Positions=595;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZM6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005262 calcium channel activity GO:0005509 calcium ion binding
Biological Process: GO:0006811 ion transport GO:0008150 biological_process GO:0050982 detection of mechanical stimulus GO:0070588 calcium ion transmembrane transport
Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
BC034619 - Homo sapiens polycystic kidney disease 2-like 2, mRNA (cDNA clone IMAGE:4838523). BC044581 - Homo sapiens polycystic kidney disease 2-like 2, mRNA (cDNA clone MGC:57172 IMAGE:4830805), complete cds. BC038714 - Homo sapiens polycystic kidney disease 2-like 2, mRNA (cDNA clone IMAGE:5268481). AK301924 - Homo sapiens cDNA FLJ60937 complete cds, highly similar to Polycystic kidney disease 2-like 2 protein. AF182034 - Homo sapiens polycystic kidney disease-like 2 protein (PKDL2) mRNA, complete cds. AF118125 - Homo sapiens polycystin-2-like protein (PKD2L2) mRNA, complete cds. CU692208 - Synthetic construct Homo sapiens gateway clone IMAGE:100020935 5' read PKD2L2 mRNA. KJ902447 - Synthetic construct Homo sapiens clone ccsbBroadEn_11841 PKD2L2 gene, encodes complete protein. JD359468 - Sequence 340492 from Patent EP1572962. JD056901 - Sequence 37925 from Patent EP1572962.
US Server
