Human Gene GFRA3 (ENST00000274721.8) from GENCODE V44
Description: Homo sapiens GDNF family receptor alpha 3 (GFRA3), mRNA. (from RefSeq NM_001496) RefSeq Summary (NM_001496): The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000274721.8 Gencode Gene: ENSG00000146013.11 Transcript (Including UTRs) Position: hg38 chr5:138,252,380-138,274,621 Size: 22,242 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr5:138,252,968-138,274,424 Size: 21,457 Coding Exon Count: 8
ID:GFRA3_HUMAN DESCRIPTION: RecName: Full=GDNF family receptor alpha-3; Short=GDNF receptor alpha-3; Short=GDNFR-alpha-3; Short=GFR-alpha-3; Flags: Precursor; FUNCTION: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. PTM: N-glycosylated. SIMILARITY: Belongs to the GDNFR family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60609
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.