Human Gene DNAJC18 (ENST00000302060.10) from GENCODE V44
  Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member C18 (DNAJC18), mRNA. (from RefSeq NM_152686)
Gencode Transcript: ENST00000302060.10
Gencode Gene: ENSG00000170464.10
Transcript (Including UTRs)
   Position: hg38 chr5:139,410,203-139,439,525 Size: 29,323 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr5:139,414,148-139,439,445 Size: 25,298 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:139,410,203-139,439,525)mRNA (may differ from genome)Protein (358 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DJC18_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 18;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 1 J domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.80 RPKM in Testis
Total median expression: 221.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.7080-0.334 Picture PostScript Text
3' UTR -1265.703945-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR015399 - DUF1977_DnaJ-like
IPR018253 - Heat_shock_DnaJ_CS
IPR003095 - Hsp_DnaJ

Pfam Domains:
PF00226 - DnaJ domain
PF09320 - Domain of unknown function (DUF1977)

ModBase Predicted Comparative 3D Structure on Q9H819
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  JD546593 - Sequence 527617 from Patent EP1572962.
BC030162 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 18, mRNA (cDNA clone MGC:29463 IMAGE:5020970), complete cds.
AK024054 - Homo sapiens cDNA FLJ13992 fis, clone Y79AA1002139, weakly similar to DNAJ PROTEIN HOMOLOG 1.
JD343331 - Sequence 324355 from Patent EP1572962.
JD119477 - Sequence 100501 from Patent EP1572962.
JD142734 - Sequence 123758 from Patent EP1572962.
JD058290 - Sequence 39314 from Patent EP1572962.
JD246660 - Sequence 227684 from Patent EP1572962.
JD155765 - Sequence 136789 from Patent EP1572962.
AK001329 - Homo sapiens cDNA FLJ10467 fis, clone NT2RP2000006, weakly similar to DNAJ PROTEIN.
JD431422 - Sequence 412446 from Patent EP1572962.
JD327004 - Sequence 308028 from Patent EP1572962.
JD042076 - Sequence 23100 from Patent EP1572962.
JD095809 - Sequence 76833 from Patent EP1572962.
JD155515 - Sequence 136539 from Patent EP1572962.
JD431421 - Sequence 412445 from Patent EP1572962.
JD042075 - Sequence 23099 from Patent EP1572962.
JD472525 - Sequence 453549 from Patent EP1572962.
JD376835 - Sequence 357859 from Patent EP1572962.
JD445286 - Sequence 426310 from Patent EP1572962.
JD294262 - Sequence 275286 from Patent EP1572962.
JD432652 - Sequence 413676 from Patent EP1572962.
JD481642 - Sequence 462666 from Patent EP1572962.
JD238247 - Sequence 219271 from Patent EP1572962.
JD238246 - Sequence 219270 from Patent EP1572962.
JD396074 - Sequence 377098 from Patent EP1572962.
JD426885 - Sequence 407909 from Patent EP1572962.
JD280656 - Sequence 261680 from Patent EP1572962.
JD489685 - Sequence 470709 from Patent EP1572962.
JD375072 - Sequence 356096 from Patent EP1572962.
JD515707 - Sequence 496731 from Patent EP1572962.
JD132019 - Sequence 113043 from Patent EP1572962.
JD449430 - Sequence 430454 from Patent EP1572962.
JD138779 - Sequence 119803 from Patent EP1572962.
JD382439 - Sequence 363463 from Patent EP1572962.
JD348933 - Sequence 329957 from Patent EP1572962.
JD130571 - Sequence 111595 from Patent EP1572962.
JD492403 - Sequence 473427 from Patent EP1572962.
JD474535 - Sequence 455559 from Patent EP1572962.
JD179005 - Sequence 160029 from Patent EP1572962.
JD492402 - Sequence 473426 from Patent EP1572962.
JD353626 - Sequence 334650 from Patent EP1572962.
JD145244 - Sequence 126268 from Patent EP1572962.
JD082056 - Sequence 63080 from Patent EP1572962.
JD242180 - Sequence 223204 from Patent EP1572962.
JD195702 - Sequence 176726 from Patent EP1572962.
JD083789 - Sequence 64813 from Patent EP1572962.
JD380481 - Sequence 361505 from Patent EP1572962.
JD208431 - Sequence 189455 from Patent EP1572962.
JD355295 - Sequence 336319 from Patent EP1572962.
JD560361 - Sequence 541385 from Patent EP1572962.
JD208465 - Sequence 189489 from Patent EP1572962.
JD295161 - Sequence 276185 from Patent EP1572962.
JD234829 - Sequence 215853 from Patent EP1572962.
JD223988 - Sequence 205012 from Patent EP1572962.
JD076974 - Sequence 57998 from Patent EP1572962.
JD240331 - Sequence 221355 from Patent EP1572962.
JD369045 - Sequence 350069 from Patent EP1572962.
AK308138 - Homo sapiens cDNA, FLJ98086.
HQ447774 - Synthetic construct Homo sapiens clone IMAGE:100071105; CCSB012588_04 DnaJ (Hsp40) homolog, subfamily C, member 18 (DNAJC18) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: DJC18_HUMAN, ENST00000302060.1, ENST00000302060.2, ENST00000302060.3, ENST00000302060.4, ENST00000302060.5, ENST00000302060.6, ENST00000302060.7, ENST00000302060.8, ENST00000302060.9, NM_152686, Q9H819, uc003len.1, uc003len.2, uc003len.3, uc003len.4, uc003len.5
UCSC ID: ENST00000302060.10
RefSeq Accession: NM_152686
Protein: Q9H819 (aka DJC18_HUMAN)
CCDS: CCDS4214.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.