Human Gene DRD1 (ENST00000393752.3) from GENCODE V44
Description: Homo sapiens dopamine receptor D1 (DRD1), mRNA. (from RefSeq NM_000794) RefSeq Summary (NM_000794): This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000393752.3 Gencode Gene: ENSG00000184845.4 Transcript (Including UTRs) Position: hg38 chr5:175,440,036-175,444,182 Size: 4,147 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr5:175,441,759-175,443,099 Size: 1,341 Coding Exon Count: 1
ID:DRD1_HUMAN DESCRIPTION: RecName: Full=D(1A) dopamine receptor; AltName: Full=Dopamine D1 receptor; FUNCTION: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. SUBUNIT: Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (By similarity). TISSUE SPECIFICITY: Detected in caudate, nucleus accumbens and in the olfactory tubercle. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P21728
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
