Human Gene CLTB (ENST00000310418.9) from GENCODE V44
Description: Homo sapiens clathrin light chain B (CLTB), transcript variant 6, non-coding RNA. (from RefSeq NR_157088) RefSeq Summary (NM_007097): Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000310418.9 Gencode Gene: ENSG00000175416.16 Transcript (Including UTRs) Position: hg38 chr5:176,392,501-176,416,539 Size: 24,039 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr5:176,392,774-176,416,363 Size: 23,590 Coding Exon Count: 6
ID:CLCB_HUMAN DESCRIPTION: RecName: Full=Clathrin light chain B; Short=Lcb; FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. SUBUNIT: Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts (via N-terminus) with HIP1. Interacts with HIP1R. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles. SIMILARITY: Belongs to the clathrin light chain family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09497
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0016192 vesicle-mediated transport GO:0061024 membrane organization GO:0072583 clathrin-dependent endocytosis