Human Gene SCGN (ENST00000377961.3) from GENCODE V44
Description: Homo sapiens secretagogin, EF-hand calcium binding protein (SCGN), mRNA. (from RefSeq NM_006998) RefSeq Summary (NM_006998): The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000377961.3 Gencode Gene: ENSG00000079689.15 Transcript (Including UTRs) Position: hg38 chr6:25,652,215-25,701,783 Size: 49,569 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr6:25,652,404-25,701,335 Size: 48,932 Coding Exon Count: 11
ID:SEGN_HUMAN DESCRIPTION: RecName: Full=Secretagogin; SUBCELLULAR LOCATION: Cytoplasm. Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. TISSUE SPECIFICITY: Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. SIMILARITY: Contains 6 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O76038
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.