Human Gene MLN (ENST00000430124.7) from GENCODE V44
Description: Homo sapiens motilin (MLN), transcript variant 1, mRNA. (from RefSeq NM_002418) RefSeq Summary (NM_002418): This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000430124.7 Gencode Gene: ENSG00000096395.11 Transcript (Including UTRs) Position: hg38 chr6:33,794,673-33,804,003 Size: 9,331 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr6:33,794,825-33,801,163 Size: 6,339 Coding Exon Count: 4
ID:MOTI_HUMAN DESCRIPTION: RecName: Full=Promotilin; Contains: RecName: Full=Motilin; Contains: RecName: Full=Motilin-associated peptide; Short=MAP; Flags: Precursor; FUNCTION: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the motilin family. WEB RESOURCE: Name=Wikipedia; Note=Motilin entry; URL="http://en.wikipedia.org/wiki/Motilin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12872
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary