Human Gene GLP1R (ENST00000373256.5) from GENCODE V44
Description: Homo sapiens glucagon like peptide 1 receptor (GLP1R), transcript variant 3, non-coding RNA. (from RefSeq NR_136563) RefSeq Summary (NM_002062): This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]. Gencode Transcript: ENST00000373256.5 Gencode Gene: ENSG00000112164.6 Transcript (Including UTRs) Position: hg38 chr6:39,048,781-39,091,303 Size: 42,523 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr6:39,048,841-39,086,073 Size: 37,233 Coding Exon Count: 13
ID:GLP1R_HUMAN DESCRIPTION: RecName: Full=Glucagon-like peptide 1 receptor; Short=GLP-1 receptor; Short=GLP-1-R; Short=GLP-1R; Flags: Precursor; FUNCTION: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. SUBUNIT: May form homodimers and heterodimers with GIPR. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. PTM: N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/glp1r/"; WEB RESOURCE: Name=Wikipedia; Note=Glucagon-like peptide 1 entry; URL="http://en.wikipedia.org/wiki/Glucagon-like_peptide-1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P43220
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.