Human Gene KCNK17 (ENST00000373231.9) from GENCODE V44
Description: Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA. (from RefSeq NM_031460) RefSeq Summary (NM_031460): The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]. Gencode Transcript: ENST00000373231.9 Gencode Gene: ENSG00000124780.14 Transcript (Including UTRs) Position: hg38 chr6:39,299,001-39,314,419 Size: 15,419 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr6:39,299,427-39,314,320 Size: 14,894 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96T54
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005244 voltage-gated ion channel activity GO:0005267 potassium channel activity GO:0022841 potassium ion leak channel activity
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0030322 stabilization of membrane potential GO:0034765 regulation of ion transmembrane transport GO:0071805 potassium ion transmembrane transport