Human Gene KCNK17 (ENST00000373231.9) from GENCODE V44
  Description: Homo sapiens potassium two pore domain channel subfamily K member 17 (KCNK17), transcript variant 1, mRNA. (from RefSeq NM_031460)
RefSeq Summary (NM_031460): The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Gencode Transcript: ENST00000373231.9
Gencode Gene: ENSG00000124780.14
Transcript (Including UTRs)
   Position: hg38 chr6:39,299,001-39,314,419 Size: 15,419 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr6:39,299,427-39,314,320 Size: 14,894 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:39,299,001-39,314,419)mRNA (may differ from genome)Protein (332 aa)
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OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KCNKH_HUMAN
DESCRIPTION: RecName: Full=Potassium channel subfamily K member 17; AltName: Full=2P domain potassium channel Talk-2; AltName: Full=Acid-sensitive potassium channel protein TASK-4; AltName: Full=TWIK-related acid-sensitive K(+) channel 4; AltName: Full=TWIK-related alkaline pH-activated K(+) channel 2; Short=TALK-2;
FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
SUBUNIT: Homodimer (Potential).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
MISCELLANEOUS: Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.
SIMILARITY: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
SEQUENCE CAUTION: Sequence=AAK28551.1; Type=Frameshift; Positions=260;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KCNK17
Diseases sorted by gene-association score: cerebral hemorrhage (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.87 RPKM in Artery - Aorta
Total median expression: 41.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.7099-0.371 Picture PostScript Text
3' UTR -121.30426-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003280 - 2pore_dom_K_chnl
IPR003092 - 2pore_dom_K_chnl_TASK
IPR022306 - 2pore_dom_K_chnl_TASK/TWIK
IPR013099 - Ion_trans_2

Pfam Domains:
PF07885 - Ion channel

ModBase Predicted Comparative 3D Structure on Q96T54
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0022841 potassium ion leak channel activity

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0030322 stabilization of membrane potential
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC025726 - Homo sapiens potassium channel, subfamily K, member 17, mRNA (cDNA clone MGC:34117 IMAGE:5201326), complete cds.
AY358853 - Homo sapiens clone DNA129591 TASK-4 (UNQ5816) mRNA, complete cds.
JD246341 - Sequence 227365 from Patent EP1572962.
AF339912 - Homo sapiens potassium channel TASK-4 mRNA, complete cds.
JD152608 - Sequence 133632 from Patent EP1572962.
JD510951 - Sequence 491975 from Patent EP1572962.
EU978944 - Homo sapiens K2P17.1 potassium channel (KCNK17) mRNA, complete cds.
JD289346 - Sequence 270370 from Patent EP1572962.
JD112711 - Sequence 93735 from Patent EP1572962.
JD330891 - Sequence 311915 from Patent EP1572962.
JD037967 - Sequence 18991 from Patent EP1572962.
JD202218 - Sequence 183242 from Patent EP1572962.
AF358910 - Homo sapiens 2P domain potassium channel Talk-2 (KCNK17) mRNA, complete cds.
DQ891712 - Synthetic construct clone IMAGE:100004342; FLH179332.01X; RZPDo839F04130D potassium channel, subfamily K, member 17 (KCNK17) gene, encodes complete protein.
AK315273 - Homo sapiens cDNA, FLJ96285, highly similar to Homo sapiens potassium channel, subfamily K, member 17 (KCNK17), mRNA.
DQ894889 - Synthetic construct Homo sapiens clone IMAGE:100009349; FLH179328.01L; RZPDo839F04129D potassium channel, subfamily K, member 17 (KCNK17) gene, encodes complete protein.
KJ904937 - Synthetic construct Homo sapiens clone ccsbBroadEn_14331 KCNK17 gene, encodes complete protein.
CU693040 - Synthetic construct Homo sapiens gateway clone IMAGE:100018121 5' read KCNK17 mRNA.
AK310582 - Homo sapiens cDNA, FLJ17624.
JD479957 - Sequence 460981 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96T54 (Reactome details) participates in the following event(s):

R-HSA-1299359 Activation of TALK
R-HSA-5578910 KCNK dimers transport K+ from cytosol to extracellular region
R-HSA-1299361 TWIK-related alkaline pH activated K+ channel (TALK)
R-HSA-5576886 Phase 4 - resting membrane potential
R-HSA-1296346 Tandem pore domain potassium channels
R-HSA-5576891 Cardiac conduction
R-HSA-1296071 Potassium Channels
R-HSA-397014 Muscle contraction
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373231.1, ENST00000373231.2, ENST00000373231.3, ENST00000373231.4, ENST00000373231.5, ENST00000373231.6, ENST00000373231.7, ENST00000373231.8, KCNKH_HUMAN, NM_031460, Q5TCF4, Q8TAW4, Q96T54, Q9BXD1, Q9H592, TALK2, TASK4, uc003ooo.1, uc003ooo.2, uc003ooo.3, uc003ooo.4, uc003ooo.5, UNQ5816/PRO19634
UCSC ID: ENST00000373231.9
RefSeq Accession: NM_031460
Protein: Q96T54 (aka KCNKH_HUMAN or CIWH_HUMAN)
CCDS: CCDS4842.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.