Human Gene KIF6 (ENST00000287152.12) from GENCODE V44
Description: Homo sapiens kinesin family member 6 (KIF6), transcript variant 1, mRNA. (from RefSeq NM_145027) RefSeq Summary (NM_145027): This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]. Gencode Transcript: ENST00000287152.12 Gencode Gene: ENSG00000164627.18 Transcript (Including UTRs) Position: hg38 chr6:39,329,990-39,725,408 Size: 395,419 Total Exon Count: 23 Strand: - Coding Region Position: hg38 chr6:39,336,532-39,725,310 Size: 388,779 Coding Exon Count: 23
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZMV9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ904031 - Synthetic construct Homo sapiens clone ccsbBroadEn_13425 KIF6 gene, encodes complete protein. KR709508 - Synthetic construct Homo sapiens clone CCSBHm_00002861 KIF6 (KIF6) mRNA, encodes complete protein. AL832634 - Homo sapiens mRNA; cDNA DKFZp451I2418 (from clone DKFZp451I2418). BX649045 - Homo sapiens mRNA; cDNA DKFZp779L1313 (from clone DKFZp779L1313). AK131471 - Homo sapiens cDNA FLJ16639 fis, clone TESTI4026207, weakly similar to Kinesin-like protein KLP1. BC143444 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:176969 IMAGE:9051952), complete cds. BC143445 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:176970 IMAGE:9051953), complete cds. BC117307 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:150916 IMAGE:40125858), complete cds. KJ904032 - Synthetic construct Homo sapiens clone ccsbBroadEn_13426 KIF6 gene, encodes complete protein. BC043552 - Homo sapiens, clone IMAGE:5174044, mRNA. AK097521 - Homo sapiens cDNA FLJ40202 fis, clone TESTI2020344. JD471686 - Sequence 452710 from Patent EP1572962. JD130713 - Sequence 111737 from Patent EP1572962. JD223831 - Sequence 204855 from Patent EP1572962. JD380085 - Sequence 361109 from Patent EP1572962. JD533748 - Sequence 514772 from Patent EP1572962. JD208663 - Sequence 189687 from Patent EP1572962. JD144665 - Sequence 125689 from Patent EP1572962. AK123217 - Homo sapiens cDNA FLJ41223 fis, clone BRAMY2029602. BC022074 - Homo sapiens kinesin family member 6, mRNA (cDNA clone IMAGE:4798479), complete cds. JD484485 - Sequence 465509 from Patent EP1572962. JD209331 - Sequence 190355 from Patent EP1572962. JD343760 - Sequence 324784 from Patent EP1572962. JD234415 - Sequence 215439 from Patent EP1572962. JD351346 - Sequence 332370 from Patent EP1572962. JD342056 - Sequence 323080 from Patent EP1572962. JD209168 - Sequence 190192 from Patent EP1572962. JD215459 - Sequence 196483 from Patent EP1572962. JD119601 - Sequence 100625 from Patent EP1572962. JD102837 - Sequence 83861 from Patent EP1572962. JD106350 - Sequence 87374 from Patent EP1572962. JD386372 - Sequence 367396 from Patent EP1572962. JD251435 - Sequence 232459 from Patent EP1572962. JD372423 - Sequence 353447 from Patent EP1572962. BC098418 - Homo sapiens kinesin family member 6, mRNA (cDNA clone IMAGE:5420694), complete cds. JD360221 - Sequence 341245 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6ZMV9 (Reactome details) participates in the following event(s):
R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-109582 Hemostasis R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport