Human Gene KIF6 (ENST00000287152.12) from GENCODE V44
  Description: Homo sapiens kinesin family member 6 (KIF6), transcript variant 1, mRNA. (from RefSeq NM_145027)
RefSeq Summary (NM_145027): This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017].
Gencode Transcript: ENST00000287152.12
Gencode Gene: ENSG00000164627.18
Transcript (Including UTRs)
   Position: hg38 chr6:39,329,990-39,725,408 Size: 395,419 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg38 chr6:39,336,532-39,725,310 Size: 388,779 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:39,329,990-39,725,408)mRNA (may differ from genome)Protein (814 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KIF6_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF6;
INTERACTION: Q92624:APPBP2; NbExp=3; IntAct=EBI-751100, EBI-743771;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIF6
Diseases sorted by gene-association score: smallpox (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.40 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 12.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.7098-0.364 Picture PostScript Text
3' UTR -2367.876542-0.362 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain

ModBase Predicted Comparative 3D Structure on Q6ZMV9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0001673 male germ cell nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  KJ904031 - Synthetic construct Homo sapiens clone ccsbBroadEn_13425 KIF6 gene, encodes complete protein.
KR709508 - Synthetic construct Homo sapiens clone CCSBHm_00002861 KIF6 (KIF6) mRNA, encodes complete protein.
AL832634 - Homo sapiens mRNA; cDNA DKFZp451I2418 (from clone DKFZp451I2418).
BX649045 - Homo sapiens mRNA; cDNA DKFZp779L1313 (from clone DKFZp779L1313).
AK131471 - Homo sapiens cDNA FLJ16639 fis, clone TESTI4026207, weakly similar to Kinesin-like protein KLP1.
BC143444 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:176969 IMAGE:9051952), complete cds.
BC143445 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:176970 IMAGE:9051953), complete cds.
BC117307 - Homo sapiens kinesin family member 6, mRNA (cDNA clone MGC:150916 IMAGE:40125858), complete cds.
KJ904032 - Synthetic construct Homo sapiens clone ccsbBroadEn_13426 KIF6 gene, encodes complete protein.
BC043552 - Homo sapiens, clone IMAGE:5174044, mRNA.
AK097521 - Homo sapiens cDNA FLJ40202 fis, clone TESTI2020344.
JD471686 - Sequence 452710 from Patent EP1572962.
JD130713 - Sequence 111737 from Patent EP1572962.
JD223831 - Sequence 204855 from Patent EP1572962.
JD380085 - Sequence 361109 from Patent EP1572962.
JD533748 - Sequence 514772 from Patent EP1572962.
JD208663 - Sequence 189687 from Patent EP1572962.
JD144665 - Sequence 125689 from Patent EP1572962.
AK123217 - Homo sapiens cDNA FLJ41223 fis, clone BRAMY2029602.
BC022074 - Homo sapiens kinesin family member 6, mRNA (cDNA clone IMAGE:4798479), complete cds.
JD484485 - Sequence 465509 from Patent EP1572962.
JD209331 - Sequence 190355 from Patent EP1572962.
JD343760 - Sequence 324784 from Patent EP1572962.
JD234415 - Sequence 215439 from Patent EP1572962.
JD351346 - Sequence 332370 from Patent EP1572962.
JD342056 - Sequence 323080 from Patent EP1572962.
JD209168 - Sequence 190192 from Patent EP1572962.
JD215459 - Sequence 196483 from Patent EP1572962.
JD119601 - Sequence 100625 from Patent EP1572962.
JD102837 - Sequence 83861 from Patent EP1572962.
JD106350 - Sequence 87374 from Patent EP1572962.
JD386372 - Sequence 367396 from Patent EP1572962.
JD251435 - Sequence 232459 from Patent EP1572962.
JD372423 - Sequence 353447 from Patent EP1572962.
BC098418 - Homo sapiens kinesin family member 6, mRNA (cDNA clone IMAGE:5420694), complete cds.
JD360221 - Sequence 341245 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6ZMV9 (Reactome details) participates in the following event(s):

R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-109582 Hemostasis
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf102, ENST00000287152.1, ENST00000287152.10, ENST00000287152.11, ENST00000287152.2, ENST00000287152.3, ENST00000287152.4, ENST00000287152.5, ENST00000287152.6, ENST00000287152.7, ENST00000287152.8, ENST00000287152.9, KIF6_HUMAN, NM_145027, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZMV9, Q6ZWE3, Q86T87, Q8WTV4, uc003oot.1, uc003oot.2, uc003oot.3, uc003oot.4
UCSC ID: ENST00000287152.12
RefSeq Accession: NM_145027
Protein: Q6ZMV9 (aka KIF6_HUMAN)
CCDS: CCDS4844.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.