Human Gene NCR2 (ENST00000373089.10) from GENCODE V44
  Description: Homo sapiens natural cytotoxicity triggering receptor 2 (NCR2), transcript variant 1, mRNA. (from RefSeq NM_004828)
Gencode Transcript: ENST00000373089.10
Gencode Gene: ENSG00000096264.14
Transcript (Including UTRs)
   Position: hg38 chr6:41,335,608-41,350,889 Size: 15,282 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr6:41,335,877-41,350,864 Size: 14,988 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:41,335,608-41,350,889)mRNA (may differ from genome)Protein (276 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Natural cytotoxicity triggering receptor 2; AltName: Full=Lymphocyte antigen 95 homolog; AltName: Full=NK cell-activating receptor; AltName: Full=Natural killer cell p44-related protein; Short=NK-p44; Short=NKp44; AltName: CD_antigen=CD336; Flags: Precursor;
FUNCTION: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
SUBUNIT: Interacts with TYROBP/DAP12.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.
SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.70 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 0.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -72.30269-0.269 Picture PostScript Text
3' UTR 0.00250.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1HKF - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on O95944
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding

Biological Process:
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0045087 innate immune response
GO:0050776 regulation of immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AJ225109 - Homo sapiens mRNA for NKp44 NK cell activating receptor.
JD314971 - Sequence 295995 from Patent EP1572962.
JD375514 - Sequence 356538 from Patent EP1572962.
AJ010099 - Homo sapiens mRNA for Natural killer cell p44-related gene 1 (NKp44RG1).
AJ010100 - Homo sapiens mRNA for Natural killer cell p44 related gene 2 (NKp44RG2).
BC166647 - Synthetic construct Homo sapiens clone IMAGE:100066373, MGC:195510 natural cytotoxicity triggering receptor 2 (NCR2) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04650 - Natural killer cell mediated cytotoxicity

Reactome (by CSHL, EBI, and GO)

Protein O95944 (Reactome details) participates in the following event(s):

R-HSA-210273 Interaction of DAP12 and NKp44
R-HSA-5696358 TREM,CD300 binds lipids
R-HSA-2172127 DAP12 interactions
R-HSA-168249 Innate Immune System
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-168256 Immune System
R-HSA-1280218 Adaptive Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373089.1, ENST00000373089.2, ENST00000373089.3, ENST00000373089.4, ENST00000373089.5, ENST00000373089.6, ENST00000373089.7, ENST00000373089.8, ENST00000373089.9, LY95, NCTR2_HUMAN, NM_004828, O95944, Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2, uc003oqh.1, uc003oqh.2, uc003oqh.3, uc003oqh.4
UCSC ID: ENST00000373089.10
RefSeq Accession: NM_004828
Protein: O95944 (aka NCTR2_HUMAN or NCT2_HUMAN)
CCDS: CCDS4855.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.