Human Gene TNFRSF21 (ENST00000296861.2) from GENCODE V44
Description: Homo sapiens TNF receptor superfamily member 21 (TNFRSF21), mRNA. (from RefSeq NM_014452) RefSeq Summary (NM_014452): This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000296861.2 Gencode Gene: ENSG00000146072.6 Transcript (Including UTRs) Position: hg38 chr6:47,231,532-47,309,905 Size: 78,374 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr6:47,232,765-47,309,511 Size: 76,747 Coding Exon Count: 6
ID:TNR21_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 21; AltName: Full=Death receptor 6; AltName: CD_antigen=CD358; Flags: Precursor; FUNCTION: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). SUBUNIT: Associates with TRADD. Interacts with N-APP (By similarity). INTERACTION: P05067:APP; NbExp=3; IntAct=EBI-2313231, EBI-77613; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable). TISSUE SPECIFICITY: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats. CAUTION: It is uncertain whether Met-1 or Met-25 is the initiator. SEQUENCE CAUTION: Sequence=AAH10241.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75509
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.