Human Gene KCNQ5 (ENST00000370398.6) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel subfamily Q member 5 (KCNQ5), transcript variant 1, mRNA. (from RefSeq NM_019842) RefSeq Summary (NM_019842): This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. Gencode Transcript: ENST00000370398.6 Gencode Gene: ENSG00000185760.18 Transcript (Including UTRs) Position: hg38 chr6:72,622,064-73,198,853 Size: 576,790 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr6:72,622,190-73,195,414 Size: 573,225 Coding Exon Count: 14
ID:KCNQ5_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily KQT member 5; AltName: Full=KQT-like 5; AltName: Full=Potassium channel subunit alpha KvLQT5; AltName: Full=Voltage-gated potassium channel subunit Kv7.5; FUNCTION: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. SUBUNIT: Heteromultimer with KCNQ3. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity). SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF03520 - KCNQ voltage-gated potassium channel
ModBase Predicted Comparative 3D Structure on Q9NR82
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005267 potassium channel activity GO:0005515 protein binding
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport