Human Gene CD109 (ENST00000287097.6) from GENCODE V44
Description: Homo sapiens CD109 molecule (CD109), transcript variant 1, mRNA. (from RefSeq NM_133493) RefSeq Summary (NM_133493): This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]. Gencode Transcript: ENST00000287097.6 Gencode Gene: ENSG00000156535.15 Transcript (Including UTRs) Position: hg38 chr6:73,696,203-73,828,313 Size: 132,111 Total Exon Count: 33 Strand: + Coding Region Position: hg38 chr6:73,696,216-73,823,633 Size: 127,418 Coding Exon Count: 33
ID:CD109_HUMAN DESCRIPTION: RecName: Full=CD109 antigen; AltName: Full=150 kDa TGF-beta-1-binding protein; AltName: Full=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; AltName: Full=Platelet-specific Gov antigen; AltName: Full=p180; AltName: Full=r150; AltName: CD_antigen=CD109; Flags: Precursor; FUNCTION: Modulates negatively TGFB1 signaling in keratinocytes. SUBUNIT: Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. PTM: N-glycosylated. PTM: 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. POLYMORPHISM: The Gov(b) variant in position 703 defines the Gov alloantigenic determinants. SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. SEQUENCE CAUTION: Sequence=BAG53987.1; Type=Erroneous initiation; Sequence=CAE46045.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAE46045.1; Type=Frameshift; Positions=1282;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00207 - Alpha-2-macroglobulin family PF07678 - A-macroglobulin complement component PF01835 - MG2 domain PF07703 - Alpha-2-macroglobulin family N-terminal region PF07677 - A-macroglobulin receptor PF10569 - Alpha-macro-globulin thiol-ester bond-forming region
ModBase Predicted Comparative 3D Structure on Q6YHK3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
