Human Gene TTK (ENST00000369798.7) from GENCODE V44
Description: Homo sapiens TTK protein kinase (TTK), transcript variant 1, mRNA. (from RefSeq NM_003318) RefSeq Summary (NM_003318): This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]. Gencode Transcript: ENST00000369798.7 Gencode Gene: ENSG00000112742.10 Transcript (Including UTRs) Position: hg38 chr6:80,004,649-80,042,527 Size: 37,879 Total Exon Count: 22 Strand: + Coding Region Position: hg38 chr6:80,005,844-80,042,202 Size: 36,359 Coding Exon Count: 21
ID:TTK_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein kinase TTK; EC=2.7.12.1; AltName: Full=Phosphotyrosine picked threonine-protein kinase; Short=PYT; FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Inhibited by the ATP-competitive kinase inhibitor, SP600125. TISSUE SPECIFICITY: Present in rapidly proliferating cell lines. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAA61239.1; Type=Erroneous initiation; Sequence=CAB87580.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P33981
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
