ID:PNRC1_HUMAN DESCRIPTION: RecName: Full=Proline-rich nuclear receptor coactivator 1; AltName: Full=Proline-rich protein 2; AltName: Full=Protein B4-2; FUNCTION: Nuclear receptor coactivator. May play a role in signal transduction. SUBUNIT: Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2. INTERACTION: Q9H1D9:POLR3F; NbExp=3; IntAct=EBI-2827376, EBI-710067; SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed in liver, lung, fat and NK/T cells. DOMAIN: The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif. SIMILARITY: Belongs to the PNRC family. PNRC1 subfamily. SEQUENCE CAUTION: Sequence=CAI16244.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q12796
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
