Human Gene ASCC3 (ENST00000369162.7) from GENCODE V44
Description: Homo sapiens activating signal cointegrator 1 complex subunit 3 (ASCC3), transcript variant 1, mRNA. (from RefSeq NM_006828) RefSeq Summary (NM_006828): This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000369162.7 Gencode Gene: ENSG00000112249.14 Transcript (Including UTRs) Position: hg38 chr6:100,508,194-100,881,329 Size: 373,136 Total Exon Count: 42 Strand: - Coding Region Position: hg38 chr6:100,509,386-100,867,997 Size: 358,612 Coding Exon Count: 41
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N3C0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006307 DNA dealkylation involved in DNA repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0008283 cell proliferation GO:0032508 DNA duplex unwinding
AY013288 - Homo sapiens ASC-1 complex subunit P200 mRNA, partial cds. AL834463 - Homo sapiens mRNA; cDNA DKFZp762E1710 (from clone DKFZp762E1710). AB587335 - Synthetic construct DNA, clone: pF1KB8595, Homo sapiens ASCC3 gene for activating signal cointegrator 1 complex subunit 3, without stop codon, in Flexi system. AM393382 - Synthetic construct Homo sapiens clone IMAGE:100001999 for hypothetical protein (ASCC3 gene). BC150215 - Synthetic construct Homo sapiens clone IMAGE:100001999, MGC:165124 activating signal cointegrator 1 complex subunit 3 (ASCC3) mRNA, encodes complete protein. AK299117 - Homo sapiens cDNA FLJ56882 partial cds, highly similar to Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-). AJ223948 - Homo sapiens mRNA for putative RNA helicase, 3' end. BC039857 - Homo sapiens activating signal cointegrator 1 complex subunit 3, mRNA (cDNA clone IMAGE:4539514). BC026066 - Homo sapiens activating signal cointegrator 1 complex subunit 3, mRNA (cDNA clone IMAGE:4830875), complete cds. BC014358 - Homo sapiens activating signal cointegrator 1 complex subunit 3, mRNA (cDNA clone IMAGE:3828119), with apparent retained intron. LF378719 - JP 2014500723-A/186222: Polycomb-Associated Non-Coding RNAs. MA614296 - JP 2018138019-A/186222: Polycomb-Associated Non-Coding RNAs. JD359244 - Sequence 340268 from Patent EP1572962. JD479673 - Sequence 460697 from Patent EP1572962. JD263968 - Sequence 244992 from Patent EP1572962. LF378718 - JP 2014500723-A/186221: Polycomb-Associated Non-Coding RNAs. MA614295 - JP 2018138019-A/186221: Polycomb-Associated Non-Coding RNAs. JD019681 - Sequence 705 from Patent EP1572962. JD032443 - Sequence 13467 from Patent EP1572962. JD029548 - Sequence 10572 from Patent EP1572962. CR936692 - Homo sapiens mRNA; cDNA DKFZp686H19247 (from clone DKFZp686H19247). AK307903 - Homo sapiens cDNA, FLJ97851. AK023189 - Homo sapiens cDNA FLJ13127 fis, clone NT2RP3002911. BC125211 - Homo sapiens activating signal cointegrator 1 complex subunit 3, mRNA (cDNA clone IMAGE:40123540), complete cds. BC125212 - Homo sapiens activating signal cointegrator 1 complex subunit 3, mRNA (cDNA clone IMAGE:40123543), complete cds. BC130038 - Homo sapiens cDNA clone IMAGE:40123545, containing frame-shift errors. BC050681 - Homo sapiens activating signal cointegrator 1 complex subunit 3, mRNA (cDNA clone IMAGE:6157156), complete cds. AK315197 - Homo sapiens cDNA, FLJ96182, Homo sapiens dJ467N11.1 protein (DJ467N11.1), mRNA. KJ893187 - Synthetic construct Homo sapiens clone ccsbBroadEn_02581 ASCC3 gene, encodes complete protein. CU690764 - Synthetic construct Homo sapiens gateway clone IMAGE:100021224 5' read ASCC3 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N3C0 (Reactome details) participates in the following event(s):
R-HSA-5657617 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC R-HSA-5657637 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA R-HSA-5657642 ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA R-HSA-112123 Oxidative demethylation of 1-meA damaged DNA By ALKBH3 R-HSA-112124 Oxidative demethylation of 3-meC damaged DNA By ALKBH3 R-HSA-112125 Oxidative dealkylation of 1-EtA damaged DNA by ABH3 R-HSA-112126 ALKBH3 mediated reversal of alkylation damage R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases R-HSA-73942 DNA Damage Reversal R-HSA-73894 DNA Repair
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