Human Gene RSPO3 (ENST00000356698.9) from GENCODE V44
Description: Homo sapiens R-spondin 3 (RSPO3), mRNA. (from RefSeq NM_032784) RefSeq Summary (NM_032784): This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000356698.9 Gencode Gene: ENSG00000146374.14 Transcript (Including UTRs) Position: hg38 chr6:127,118,671-127,199,481 Size: 80,811 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr6:127,119,193-127,196,007 Size: 76,815 Coding Exon Count: 5
ID:RSPO3_HUMAN DESCRIPTION: RecName: Full=R-spondin-3; AltName: Full=Protein with TSP type-1 repeat; Short=hPWTSR; AltName: Full=Roof plate-specific spondin-3; Short=hRspo3; AltName: Full=Thrombospondin type-1 domain-containing protein 2; Flags: Precursor; FUNCTION: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity). SUBUNIT: Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. DOMAIN: The FU repeats are required for activation and stabilization of beta-catenin (By similarity). MISCELLANEOUS: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis. SIMILARITY: Belongs to the R-spondin family. SIMILARITY: Contains 2 FU (furin-like) repeats. SIMILARITY: Contains 1 TSP type-1 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00090 - Thrombospondin type 1 domain
ModBase Predicted Comparative 3D Structure on Q9BXY4
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
