Human Gene OLIG3 (ENST00000367734.4) from GENCODE V44
  Description: Homo sapiens oligodendrocyte transcription factor 3 (OLIG3), mRNA. (from RefSeq NM_175747)
Gencode Transcript: ENST00000367734.4
Gencode Gene: ENSG00000177468.7
Transcript (Including UTRs)
   Position: hg38 chr6:137,492,199-137,494,394 Size: 2,196 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chr6:137,493,352-137,494,170 Size: 819 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:137,492,199-137,494,394)mRNA (may differ from genome)Protein (272 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Oligodendrocyte transcription factor 3; Short=Oligo3; AltName: Full=Class B basic helix-loop-helix protein 7; Short=bHLHb7; AltName: Full=Class E basic helix-loop-helix protein 20; Short=bHLHe20;
FUNCTION: May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
SEQUENCE CAUTION: Sequence=DAA00303.1; Type=Erroneous initiation;

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.01 RPKM in Testis
Total median expression: 0.03 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.10224-0.308 Picture PostScript Text
3' UTR -362.801153-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q7RTU3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010468 regulation of gene expression
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021522 spinal cord motor neuron differentiation
GO:0097476 spinal cord motor neuron migration

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  KJ895748 - Synthetic construct Homo sapiens clone ccsbBroadEn_05142 OLIG3 gene, encodes complete protein.
LF212332 - JP 2014500723-A/19835: Polycomb-Associated Non-Coding RNAs.
MA447909 - JP 2018138019-A/19835: Polycomb-Associated Non-Coding RNAs.
LF213178 - JP 2014500723-A/20681: Polycomb-Associated Non-Coding RNAs.
MA448755 - JP 2018138019-A/20681: Polycomb-Associated Non-Coding RNAs.
LF208707 - JP 2014500723-A/16210: Polycomb-Associated Non-Coding RNAs.
MA444284 - JP 2018138019-A/16210: Polycomb-Associated Non-Coding RNAs.
AK096362 - Homo sapiens cDNA FLJ39043 fis, clone NT2RP7010235, highly similar to Mus musculus mRNA for Olig3 bHLH protein.
BC051352 - Homo sapiens oligodendrocyte transcription factor 3, mRNA (cDNA clone MGC:59879 IMAGE:6584192), complete cds.
JD147213 - Sequence 128237 from Patent EP1572962.
JD141099 - Sequence 122123 from Patent EP1572962.
LF321927 - JP 2014500723-A/129430: Polycomb-Associated Non-Coding RNAs.
MA557504 - JP 2018138019-A/129430: Polycomb-Associated Non-Coding RNAs.
JD510979 - Sequence 492003 from Patent EP1572962.
JD139520 - Sequence 120544 from Patent EP1572962.
JD359721 - Sequence 340745 from Patent EP1572962.
JD380866 - Sequence 361890 from Patent EP1572962.
JD156741 - Sequence 137765 from Patent EP1572962.
JD380850 - Sequence 361874 from Patent EP1572962.
JD128194 - Sequence 109218 from Patent EP1572962.
EU446887 - Synthetic construct Homo sapiens clone IMAGE:100069972; IMAGE:100012096; FLH257054.01L oligodendrocyte transcription factor 3 (OLIG3) gene, encodes complete protein.
AB465191 - Synthetic construct DNA, clone: pF1KB9636, Homo sapiens OLIG3 gene for oligodendrocyte transcription factor 3, without stop codon, in Flexi system.
CU690810 - Synthetic construct Homo sapiens gateway clone IMAGE:100022413 5' read OLIG3 mRNA.
LF321926 - JP 2014500723-A/129429: Polycomb-Associated Non-Coding RNAs.
MA557503 - JP 2018138019-A/129429: Polycomb-Associated Non-Coding RNAs.
JD217782 - Sequence 198806 from Patent EP1572962.
JD130054 - Sequence 111078 from Patent EP1572962.
JD459388 - Sequence 440412 from Patent EP1572962.
JD161205 - Sequence 142229 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BHLHB7, BHLHE20, ENST00000367734.1, ENST00000367734.2, ENST00000367734.3, NM_175747, OLIG3_HUMAN, Q7RTU3, Q8N8Q0, uc003qhp.1, uc003qhp.2, uc003qhp.3
UCSC ID: ENST00000367734.4
RefSeq Accession: NM_175747
Protein: Q7RTU3 (aka OLIG3_HUMAN or OLG3_HUMAN)
CCDS: CCDS5186.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.