ID:OLIG3_HUMAN DESCRIPTION: RecName: Full=Oligodendrocyte transcription factor 3; Short=Oligo3; AltName: Full=Class B basic helix-loop-helix protein 7; Short=bHLHb7; AltName: Full=Class E basic helix-loop-helix protein 20; Short=bHLHe20; FUNCTION: May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SEQUENCE CAUTION: Sequence=DAA00303.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7RTU3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001106 RNA polymerase II transcription corepressor activity GO:0003677 DNA binding GO:0005515 protein binding GO:0046983 protein dimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0010468 regulation of gene expression GO:0021520 spinal cord motor neuron cell fate specification GO:0021522 spinal cord motor neuron differentiation GO:0097476 spinal cord motor neuron migration