Human Gene NMBR (ENST00000258042.2) from GENCODE V44
Description: Homo sapiens neuromedin B receptor (NMBR), transcript variant 1, mRNA. (from RefSeq NM_002511) RefSeq Summary (NM_002511): This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]. Sequence Note:. Gencode Transcript: ENST00000258042.2 Gencode Gene: ENSG00000135577.5 Transcript (Including UTRs) Position: hg38 chr6:142,074,484-142,147,122 Size: 72,639 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr6:142,075,648-142,088,658 Size: 13,011 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P28336
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.