Human Gene PRR18 (ENST00000322583.5) from GENCODE V44
  Description: Homo sapiens proline rich 18 (PRR18), mRNA. (from RefSeq NM_175922)
Gencode Transcript: ENST00000322583.5
Gencode Gene: ENSG00000176381.6
Transcript (Including UTRs)
   Position: hg38 chr6:166,305,300-166,308,392 Size: 3,093 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chr6:166,307,255-166,308,142 Size: 888 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:166,305,300-166,308,392)mRNA (may differ from genome)Protein (295 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.98 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 113.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -124.50250-0.498 Picture PostScript Text
3' UTR -633.301955-0.324 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003388 - Reticulon

ModBase Predicted Comparative 3D Structure on Q8N4B5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC034775 - Homo sapiens proline rich 18, mRNA (cDNA clone MGC:35308 IMAGE:5177440), complete cds.
JD486806 - Sequence 467830 from Patent EP1572962.
JD533585 - Sequence 514609 from Patent EP1572962.
JD239332 - Sequence 220356 from Patent EP1572962.
JD051746 - Sequence 32770 from Patent EP1572962.
JD152647 - Sequence 133671 from Patent EP1572962.
JD510476 - Sequence 491500 from Patent EP1572962.
LF212688 - JP 2014500723-A/20191: Polycomb-Associated Non-Coding RNAs.
MA448265 - JP 2018138019-A/20191: Polycomb-Associated Non-Coding RNAs.
JD099249 - Sequence 80273 from Patent EP1572962.
JD142047 - Sequence 123071 from Patent EP1572962.
JD383689 - Sequence 364713 from Patent EP1572962.
JD470100 - Sequence 451124 from Patent EP1572962.
LF340099 - JP 2014500723-A/147602: Polycomb-Associated Non-Coding RNAs.
MA575676 - JP 2018138019-A/147602: Polycomb-Associated Non-Coding RNAs.
JD176795 - Sequence 157819 from Patent EP1572962.
JD215780 - Sequence 196804 from Patent EP1572962.
JD226621 - Sequence 207645 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000322583.1, ENST00000322583.2, ENST00000322583.3, ENST00000322583.4, NM_175922, PRR18_HUMAN, Q8N4B5, uc003quw.1, uc003quw.2, uc003quw.3
UCSC ID: ENST00000322583.5
RefSeq Accession: NM_175922
Protein: Q8N4B5 (aka PRR18_HUMAN)
CCDS: CCDS5291.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.