Human Gene TOMM7 (ENST00000358435.9) from GENCODE V44
  Description: Homo sapiens translocase of outer mitochondrial membrane 7 (TOMM7), transcript variant 2, non-coding RNA. (from RefSeq NR_168014)
RefSeq Summary (NM_019059): This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012].
Gencode Transcript: ENST00000358435.9
Gencode Gene: ENSG00000196683.12
Transcript (Including UTRs)
   Position: hg38 chr7:22,812,974-22,822,849 Size: 9,876 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr7:22,813,170-22,822,779 Size: 9,610 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:22,812,974-22,822,849)mRNA (may differ from genome)Protein (55 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TOM7_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM7 homolog; AltName: Full=Translocase of outer membrane 7 kDa subunit homolog;
FUNCTION: Required for assembly and stability of the TOM complex.
SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
INTERACTION: Q9NS69:TOMM22; NbExp=2; IntAct=EBI-1180558, EBI-1047508;
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein.
SIMILARITY: Belongs to the Tom7 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 191.31 RPKM in Ovary
Total median expression: 5822.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.7070-0.339 Picture PostScript Text
3' UTR -46.50196-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012621 - Tom7

Pfam Domains:
PF08038 - TOM7 family

ModBase Predicted Comparative 3D Structure on Q9P0U1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity

Biological Process:
GO:0006626 protein targeting to mitochondrion
GO:0015031 protein transport
GO:0030150 protein import into mitochondrial matrix
GO:0031647 regulation of protein stability
GO:0045040 protein import into mitochondrial outer membrane
GO:0098779 mitophagy in response to mitochondrial depolarization
GO:1903955 positive regulation of protein targeting to mitochondrion

Cellular Component:
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005742 mitochondrial outer membrane translocase complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane


-  Descriptions from all associated GenBank mRNAs
  BC071973 - Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast), mRNA (cDNA clone MGC:88669 IMAGE:6278846), complete cds.
AK026520 - Homo sapiens cDNA: FLJ22867 fis, clone KAT02314.
AF150733 - Homo sapiens AD-014 protein mRNA, complete cds.
BC001732 - Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast), mRNA (cDNA clone MGC:1816 IMAGE:3355604), complete cds.
AJ011007 - Homo sapiens mRNA for 6.2 kd protein.
AF086336 - Homo sapiens full length insert cDNA clone ZD55G12.
JD317367 - Sequence 298391 from Patent EP1572962.
JD082785 - Sequence 63809 from Patent EP1572962.
JD022791 - Sequence 3815 from Patent EP1572962.
KJ894040 - Synthetic construct Homo sapiens clone ccsbBroadEn_03434 TOMM7 gene, encodes complete protein.
JD033950 - Sequence 14974 from Patent EP1572962.
CR456960 - Homo sapiens full open reading frame cDNA clone RZPDo834F0716D for gene TOMM7, translocase of outer mitochondrial membrane 7 homolog (yeast); complete cds, incl. stopcodon.
JD021717 - Sequence 2741 from Patent EP1572962.
JD033735 - Sequence 14759 from Patent EP1572962.
JD518861 - Sequence 499885 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P0U1 (Reactome details) participates in the following event(s):

R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space
R-HSA-5205661 Pink1 is recruited from the cytoplasm to the mitochondria
R-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy
R-HSA-392499 Metabolism of proteins
R-HSA-5205647 Mitophagy

-  Other Names for This Gene
  Alternate Gene Symbols: AD-014, ENST00000358435.1, ENST00000358435.2, ENST00000358435.3, ENST00000358435.4, ENST00000358435.5, ENST00000358435.6, ENST00000358435.7, ENST00000358435.8, NR_168014, O95939, Q9P0U1, TOM7, TOM7_HUMAN, TOMM07, uc003svk.1, uc003svk.2, uc003svk.3, uc003svk.4, uc003svk.5, uc003svk.6, uc003svk.7
UCSC ID: ENST00000358435.9
RefSeq Accession: NM_019059
Protein: Q9P0U1 (aka TOM7_HUMAN)
CCDS: CCDS5376.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.