Human Gene TOMM7 (ENST00000358435.9) from GENCODE V44
Description: Homo sapiens translocase of outer mitochondrial membrane 7 (TOMM7), transcript variant 2, non-coding RNA. (from RefSeq NR_168014) RefSeq Summary (NM_019059): This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]. Gencode Transcript: ENST00000358435.9 Gencode Gene: ENSG00000196683.12 Transcript (Including UTRs) Position: hg38 chr7:22,812,974-22,822,849 Size: 9,876 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr7:22,813,170-22,822,779 Size: 9,610 Coding Exon Count: 3
ID:TOM7_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM7 homolog; AltName: Full=Translocase of outer membrane 7 kDa subunit homolog; FUNCTION: Required for assembly and stability of the TOM complex. SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). INTERACTION: Q9NS69:TOMM22; NbExp=2; IntAct=EBI-1180558, EBI-1047508; SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. SIMILARITY: Belongs to the Tom7 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0U1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008320 protein transmembrane transporter activity
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0015031 protein transport GO:0030150 protein import into mitochondrial matrix GO:0031647 regulation of protein stability GO:0045040 protein import into mitochondrial outer membrane GO:0098779 mitophagy in response to mitochondrial depolarization GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component: GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0005742 mitochondrial outer membrane translocase complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0031307 integral component of mitochondrial outer membrane
Descriptions from all associated GenBank mRNAs
BC071973 - Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast), mRNA (cDNA clone MGC:88669 IMAGE:6278846), complete cds. AK026520 - Homo sapiens cDNA: FLJ22867 fis, clone KAT02314. AF150733 - Homo sapiens AD-014 protein mRNA, complete cds. BC001732 - Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast), mRNA (cDNA clone MGC:1816 IMAGE:3355604), complete cds. AJ011007 - Homo sapiens mRNA for 6.2 kd protein. AF086336 - Homo sapiens full length insert cDNA clone ZD55G12. JD317367 - Sequence 298391 from Patent EP1572962. JD082785 - Sequence 63809 from Patent EP1572962. JD022791 - Sequence 3815 from Patent EP1572962. KJ894040 - Synthetic construct Homo sapiens clone ccsbBroadEn_03434 TOMM7 gene, encodes complete protein. JD033950 - Sequence 14974 from Patent EP1572962. CR456960 - Homo sapiens full open reading frame cDNA clone RZPDo834F0716D for gene TOMM7, translocase of outer mitochondrial membrane 7 homolog (yeast); complete cds, incl. stopcodon. JD021717 - Sequence 2741 from Patent EP1572962. JD033735 - Sequence 14759 from Patent EP1572962. JD518861 - Sequence 499885 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9P0U1 (Reactome details) participates in the following event(s):
R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space R-HSA-5205661 Pink1 is recruited from the cytoplasm to the mitochondria R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-392499 Metabolism of proteins R-HSA-5205647 Mitophagy