Human Gene EVX1 (ENST00000496902.7) from GENCODE V44
  Description: Homo sapiens even-skipped homeobox 1 (EVX1), transcript variant 1, mRNA. (from RefSeq NM_001989)
RefSeq Summary (NM_001989): This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000496902.7
Gencode Gene: ENSG00000106038.13
Transcript (Including UTRs)
   Position: hg38 chr7:27,242,802-27,247,830 Size: 5,029 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr7:27,243,031-27,246,425 Size: 3,395 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:27,242,802-27,247,830)mRNA (may differ from genome)Protein (407 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
neXtProtOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Homeobox even-skipped homolog protein 1; AltName: Full=EVX-1;
FUNCTION: May play a role in the specification of neuronal cell types.
SIMILARITY: Belongs to the even-skipped homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.58 RPKM in Bladder
Total median expression: 13.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.60229-0.439 Picture PostScript Text
3' UTR -519.901405-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR020479 - Homeobox_metazoa
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

ModBase Predicted Comparative 3D Structure on P49640
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGI EnsemblEnsemblWormBase 
Protein Sequence Protein SequenceProtein SequenceProtein Sequence 
Alignment AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0009792 embryo development ending in birth or egg hatching
GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm

-  Descriptions from all associated GenBank mRNAs
  LF213036 - JP 2014500723-A/20539: Polycomb-Associated Non-Coding RNAs.
MA448613 - JP 2018138019-A/20539: Polycomb-Associated Non-Coding RNAs.
LF212034 - JP 2014500723-A/19537: Polycomb-Associated Non-Coding RNAs.
MA447611 - JP 2018138019-A/19537: Polycomb-Associated Non-Coding RNAs.
AK299188 - Homo sapiens cDNA FLJ60827 complete cds, highly similar to Homeobox even-skipped homolog protein 1.
AK314155 - Homo sapiens cDNA, FLJ94862.
X60655 - H.sapiens EVX1 mRNA.
JD126508 - Sequence 107532 from Patent EP1572962.
JD149161 - Sequence 130185 from Patent EP1572962.
JD370549 - Sequence 351573 from Patent EP1572962.
JD370550 - Sequence 351574 from Patent EP1572962.
JD373681 - Sequence 354705 from Patent EP1572962.
JD074522 - Sequence 55546 from Patent EP1572962.
JD055118 - Sequence 36142 from Patent EP1572962.
JD477802 - Sequence 458826 from Patent EP1572962.
JD140886 - Sequence 121910 from Patent EP1572962.
JD389054 - Sequence 370078 from Patent EP1572962.
BC152723 - Synthetic construct Homo sapiens clone IMAGE:100015949, MGC:184107 even-skipped homeobox 1 (EVX1) mRNA, encodes complete protein.
AK298822 - Homo sapiens cDNA FLJ51679 complete cds, highly similar to Homeobox even-skipped homolog protein 1.
JD125533 - Sequence 106557 from Patent EP1572962.
JD174045 - Sequence 155069 from Patent EP1572962.
JD218778 - Sequence 199802 from Patent EP1572962.
JD202946 - Sequence 183970 from Patent EP1572962.
JD380983 - Sequence 362007 from Patent EP1572962.
JD202964 - Sequence 183988 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D199, ENST00000496902.1, ENST00000496902.2, ENST00000496902.3, ENST00000496902.4, ENST00000496902.5, ENST00000496902.6, EVX1_HUMAN, NM_001989, P49640, uc003szd.1, uc003szd.2, uc003szd.3
UCSC ID: ENST00000496902.7
RefSeq Accession: NM_001989
Protein: P49640 (aka EVX1_HUMAN)
CCDS: CCDS5413.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.