Human Gene EVX1 (ENST00000496902.7) from GENCODE V44
Description: Homo sapiens even-skipped homeobox 1 (EVX1), transcript variant 1, mRNA. (from RefSeq NM_001989) RefSeq Summary (NM_001989): This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000496902.7 Gencode Gene: ENSG00000106038.13 Transcript (Including UTRs) Position: hg38 chr7:27,242,802-27,247,830 Size: 5,029 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr7:27,243,031-27,246,425 Size: 3,395 Coding Exon Count: 3
ID:EVX1_HUMAN DESCRIPTION: RecName: Full=Homeobox even-skipped homolog protein 1; AltName: Full=EVX-1; FUNCTION: May play a role in the specification of neuronal cell types. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the even-skipped homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49640
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0009792 embryo development ending in birth or egg hatching GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification GO:0045944 positive regulation of transcription from RNA polymerase II promoter