Human Gene CREB5 (ENST00000357727.7) from GENCODE V44
Description: Homo sapiens cAMP responsive element binding protein 5 (CREB5), transcript variant 1, mRNA. (from RefSeq NM_182898) RefSeq Summary (NM_182898): The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000357727.7 Gencode Gene: ENSG00000146592.17 Transcript (Including UTRs) Position: hg38 chr7:28,412,518-28,825,894 Size: 413,377 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr7:28,412,915-28,819,279 Size: 406,365 Coding Exon Count: 11
ID:CREB5_HUMAN DESCRIPTION: RecName: Full=Cyclic AMP-responsive element-binding protein 5; Short=CREB-5; Short=cAMP-responsive element-binding protein 5; AltName: Full=CRE-BPa; FUNCTION: Binds to the cAMP response element and activates transcription. SUBUNIT: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the bZIP family. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SIMILARITY: Contains 1 C2H2-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02930
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0045893 positive regulation of transcription, DNA-templated