Human Gene MYL7 (ENST00000223364.7) from GENCODE V44
  Description: Homo sapiens myosin light chain 7 (MYL7), mRNA. (from RefSeq NM_021223)
Gencode Transcript: ENST00000223364.7
Gencode Gene: ENSG00000106631.8
Transcript (Including UTRs)
   Position: hg38 chr7:44,138,864-44,141,332 Size: 2,469 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr7:44,138,921-44,141,305 Size: 2,385 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:44,138,864-44,141,332)mRNA (may differ from genome)Protein (175 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MLRA_HUMAN
DESCRIPTION: RecName: Full=Myosin regulatory light chain 2, atrial isoform; Short=MLC-2a; Short=MLC2a; Short=Myosin light chain 2a; AltName: Full=Myosin regulatory light chain 7;
SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
TISSUE SPECIFICITY: Predominantly expressed in adult atrial muscle.
MISCELLANEOUS: This chain binds calcium.
SIMILARITY: Contains 3 EF-hand domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MYL7
Diseases sorted by gene-association score: fechtner syndrome (5), familial atrial fibrillation (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4517.77 RPKM in Heart - Atrial Appendage
Total median expression: 4850.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.1027-0.152 Picture PostScript Text
3' UTR -14.8057-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

ModBase Predicted Comparative 3D Structure on Q01449
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006936 muscle contraction

Cellular Component:
GO:0005829 cytosol
GO:0016459 myosin complex
GO:0031672 A band
GO:0043197 dendritic spine


-  Descriptions from all associated GenBank mRNAs
  BC027915 - Homo sapiens myosin, light chain 7, regulatory, mRNA (cDNA clone MGC:34234 IMAGE:5223298), complete cds.
JD473799 - Sequence 454823 from Patent EP1572962.
M94547 - HUMMLC2At; Homo sapiens; 593 base-pairs.
AK311869 - Homo sapiens cDNA, FLJ92135, Homo sapiens myosin, light polypeptide 7, regulatory (MYL7), mRNA.
JF432610 - Synthetic construct Homo sapiens clone IMAGE:100073847 myosin, light chain 7, regulatory (MYL7) gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04510 - Focal adhesion
hsa04530 - Tight junction
hsa04670 - Leukocyte transendothelial migration
hsa04810 - Regulation of actin cytoskeleton

Reactome (by CSHL, EBI, and GO)

Protein Q01449 (Reactome details) participates in the following event(s):

R-HSA-445813 Phosphorylation of Smooth Muscle Myosin Light Chains
R-HSA-445700 Myosin Binds ATP
R-HSA-445704 Calcium Binds Caldesmon
R-HSA-445705 Release Of ADP From Myosin
R-HSA-445699 ATP Hydrolysis By Myosin
R-HSA-445355 Smooth Muscle Contraction
R-HSA-397014 Muscle contraction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4L3, ENST00000223364.1, ENST00000223364.2, ENST00000223364.3, ENST00000223364.4, ENST00000223364.5, ENST00000223364.6, MLRA_HUMAN, MYL2A, MYLC2A, NM_021223, Q01449, uc003tkg.1, uc003tkg.2, uc003tkg.3, uc003tkg.4
UCSC ID: ENST00000223364.7
RefSeq Accession: NM_021223
Protein: Q01449 (aka MLRA_HUMAN)
CCDS: CCDS5478.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.