Human Gene IGFBP1 (ENST00000275525.8) from GENCODE V44
Description: Homo sapiens insulin like growth factor binding protein 1 (IGFBP1), mRNA. (from RefSeq NM_000596) RefSeq Summary (NM_000596): This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]. Gencode Transcript: ENST00000275525.8 Gencode Gene: ENSG00000146678.10 Transcript (Including UTRs) Position: hg38 chr7:45,888,488-45,893,660 Size: 5,173 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr7:45,888,653-45,893,091 Size: 4,439 Coding Exon Count: 4
ID:IBP1_HUMAN DESCRIPTION: RecName: Full=Insulin-like growth factor-binding protein 1; Short=IBP-1; Short=IGF-binding protein 1; Short=IGFBP-1; AltName: Full=Placental protein 12; Short=PP12; Flags: Precursor; FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. SUBUNIT: Binds equally well IGF1 and IGF2. SUBCELLULAR LOCATION: Secreted. PTM: Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 1 thyroglobulin type-1 domain. SEQUENCE CAUTION: Sequence=AAA52540.1; Type=Frameshift; Positions=55, 71; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08833
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
