Human Gene TMEM130 (ENST00000416379.6) from GENCODE V44
  Description: Homo sapiens transmembrane protein 130 (TMEM130), transcript variant 1, mRNA. (from RefSeq NM_001134450)
Gencode Transcript: ENST00000416379.6
Gencode Gene: ENSG00000166448.15
Transcript (Including UTRs)
   Position: hg38 chr7:98,846,488-98,869,866 Size: 23,379 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr7:98,848,056-98,869,861 Size: 21,806 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:98,846,488-98,869,866)mRNA (may differ from genome)Protein (435 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 130; Flags: Precursor;
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type I membrane protein.
SIMILARITY: Contains 1 PKD domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 79.42 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 687.08 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -578.201568-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000601 - PKD_dom

ModBase Predicted Comparative 3D Structure on Q8N3G9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC030793 - Homo sapiens transmembrane protein 130, mRNA (cDNA clone MGC:33998 IMAGE:5263130), complete cds.
AL834349 - Homo sapiens mRNA; cDNA DKFZp761H2017 (from clone DKFZp761H2017).
AB072903 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla11882.
AL832523 - Homo sapiens mRNA; cDNA DKFZp761L1417 (from clone DKFZp761L1417).
AL834348 - Homo sapiens mRNA; cDNA DKFZp761E1917 (from clone DKFZp761E1917).
AK124634 - Homo sapiens cDNA FLJ42643 fis, clone BRACE3025531, moderately similar to Mus musculus transmembrane protein 130 (Tmem130), mRNA.
JD503594 - Sequence 484618 from Patent EP1572962.
JD161712 - Sequence 142736 from Patent EP1572962.
JD475215 - Sequence 456239 from Patent EP1572962.
JD136411 - Sequence 117435 from Patent EP1572962.
JD323132 - Sequence 304156 from Patent EP1572962.
JD460628 - Sequence 441652 from Patent EP1572962.
AK225783 - Homo sapiens mRNA for hypothetical protein LOC222865 variant, clone: FCC132A05.
JD293833 - Sequence 274857 from Patent EP1572962.
JD431705 - Sequence 412729 from Patent EP1572962.
BC037895 - Homo sapiens transmembrane protein 130, mRNA (cDNA clone MGC:43931 IMAGE:5275566), complete cds.
AY358583 - Homo sapiens clone DNA58743 AQAV719 (UNQ719) mRNA, complete cds.
JD442859 - Sequence 423883 from Patent EP1572962.
JD442858 - Sequence 423882 from Patent EP1572962.
JD444785 - Sequence 425809 from Patent EP1572962.
JD063365 - Sequence 44389 from Patent EP1572962.
JD511444 - Sequence 492468 from Patent EP1572962.
JD522239 - Sequence 503263 from Patent EP1572962.
JD073531 - Sequence 54555 from Patent EP1572962.
JD248423 - Sequence 229447 from Patent EP1572962.
JD303386 - Sequence 284410 from Patent EP1572962.
JD062901 - Sequence 43925 from Patent EP1572962.
JD103696 - Sequence 84720 from Patent EP1572962.
JD516131 - Sequence 497155 from Patent EP1572962.
JD130397 - Sequence 111421 from Patent EP1572962.
AK295543 - Homo sapiens cDNA FLJ59533 complete cds.
JD124504 - Sequence 105528 from Patent EP1572962.
JD023554 - Sequence 4578 from Patent EP1572962.
JD029650 - Sequence 10674 from Patent EP1572962.
JD473547 - Sequence 454571 from Patent EP1572962.
JD110790 - Sequence 91814 from Patent EP1572962.
JD550126 - Sequence 531150 from Patent EP1572962.
JD020551 - Sequence 1575 from Patent EP1572962.
JD267975 - Sequence 248999 from Patent EP1572962.
JD032592 - Sequence 13616 from Patent EP1572962.
AK294658 - Homo sapiens cDNA FLJ55201 complete cds, moderately similar to Mus musculus transmembrane protein 130 (Tmem130), mRNA.
JD392170 - Sequence 373194 from Patent EP1572962.
JD560300 - Sequence 541324 from Patent EP1572962.
JD265567 - Sequence 246591 from Patent EP1572962.
JD560299 - Sequence 541323 from Patent EP1572962.
JD352636 - Sequence 333660 from Patent EP1572962.
AK312364 - Homo sapiens cDNA, FLJ92685.
AM392947 - Synthetic construct Homo sapiens clone IMAGE:100001921 for hypothetical protein (TMEM130 gene).
AM393244 - Synthetic construct Homo sapiens clone IMAGE:100001916 for hypothetical protein (TMEM130 gene).
AM393838 - Synthetic construct Homo sapiens clone IMAGE:100001926 for hypothetical protein (TMEM130 gene).
AM393874 - Synthetic construct Homo sapiens clone IMAGE:100001904 for hypothetical protein (TMEM130 gene).
AB528254 - Synthetic construct DNA, clone: pF1KE0418, Homo sapiens TMEM130 gene for transmembrane protein 130, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D266, B7Z364, ENST00000416379.1, ENST00000416379.2, ENST00000416379.3, ENST00000416379.4, ENST00000416379.5, NM_001134450, Q8IY46, Q8N0W9, Q8N3G9, Q8N3R2, TM130_HUMAN, uc003upo.1, uc003upo.2, uc003upo.3, uc003upo.4, UNQ719/PRO1383
UCSC ID: ENST00000416379.6
RefSeq Accession: NM_001134450
Protein: Q8N3G9 (aka TM130_HUMAN)
CCDS: CCDS5658.1, CCDS47650.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.