Human Gene ORAI2 (ENST00000611770.5) from GENCODE V44
  Description: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1. (from UniProt Q96SN7)
Gencode Transcript: ENST00000611770.5
Gencode Gene: ENSG00000160991.17
Transcript (Including UTRs)
   Position: hg38 chr7:102,433,576-102,456,825 Size: 23,250 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr7:102,438,957-102,447,052 Size: 8,096 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:102,433,576-102,456,825)mRNA (may differ from genome)Protein (254 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDMalacardsMGIneXtProtPubMedReactome
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ORAI2_HUMAN
DESCRIPTION: RecName: Full=Protein orai-2; AltName: Full=CAP-binding protein complex-interacting protein 2; AltName: Full=Transmembrane protein 142B;
FUNCTION: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1.
SUBUNIT: Interacts with EFCAB4B/CRACR2A.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the Orai family.
SEQUENCE CAUTION: Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAP22352.1; Type=Erroneous gene model prediction; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 120.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.4099-0.600 Picture PostScript Text
3' UTR -5231.909773-0.535 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012446 - CRAC_channel

Pfam Domains:
PF07856 - Mediator of CRAC channel activity

ModBase Predicted Comparative 3D Structure on Q96SN7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity

Biological Process:
GO:0002115 store-operated calcium entry
GO:0070588 calcium ion transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030426 growth cone


-  Descriptions from all associated GenBank mRNAs
  KJ899625 - Synthetic construct Homo sapiens clone ccsbBroadEn_09019 ORAI2 gene, encodes complete protein.
AK056497 - Homo sapiens cDNA FLJ31935 fis, clone NT2RP7006408, moderately similar to Drosophila melanogaster F protein (olf186) mRNA.
AK027639 - Homo sapiens cDNA FLJ14733 fis, clone NT2RP3002014.
AK300574 - Homo sapiens cDNA FLJ58946 complete cds, highly similar to Protein orai-2.
BC069270 - Homo sapiens ORAI calcium release-activated calcium modulator 2, mRNA (cDNA clone MGC:78481 IMAGE:5477442), complete cds.
BC009183 - Homo sapiens chromosome 7 open reading frame 19, mRNA (cDNA clone IMAGE:3678268), partial cds.
AF258552 - Homo sapiens PP1729 mRNA, complete cds.
Y10777 - H.sapiens mRNA for CAP-binding protein complex interacting protein 2.
AK022536 - Homo sapiens cDNA FLJ12474 fis, clone NT2RM1000927.
JD287087 - Sequence 268111 from Patent EP1572962.
CR457287 - Homo sapiens full open reading frame cDNA clone RZPDo834G049D for gene C7orf19, chromosome 7 open reading frame 19; complete cds, incl. stopcodon.
JD426523 - Sequence 407547 from Patent EP1572962.
JD157202 - Sequence 138226 from Patent EP1572962.
JD275017 - Sequence 256041 from Patent EP1572962.
JD199735 - Sequence 180759 from Patent EP1572962.
JD200889 - Sequence 181913 from Patent EP1572962.
JD194239 - Sequence 175263 from Patent EP1572962.
JD400636 - Sequence 381660 from Patent EP1572962.
JD444625 - Sequence 425649 from Patent EP1572962.
JD222810 - Sequence 203834 from Patent EP1572962.
JD222359 - Sequence 203383 from Patent EP1572962.
JD485444 - Sequence 466468 from Patent EP1572962.
JD328883 - Sequence 309907 from Patent EP1572962.
JD299974 - Sequence 280998 from Patent EP1572962.
JD192822 - Sequence 173846 from Patent EP1572962.
JD189091 - Sequence 170115 from Patent EP1572962.
JD416907 - Sequence 397931 from Patent EP1572962.
JD394297 - Sequence 375321 from Patent EP1572962.
JD191286 - Sequence 172310 from Patent EP1572962.
JD535671 - Sequence 516695 from Patent EP1572962.
JD470052 - Sequence 451076 from Patent EP1572962.
JD473298 - Sequence 454322 from Patent EP1572962.
DQ589470 - Homo sapiens piRNA piR-56582, complete sequence.
JD216822 - Sequence 197846 from Patent EP1572962.
JD140019 - Sequence 121043 from Patent EP1572962.
JD364825 - Sequence 345849 from Patent EP1572962.
JD548689 - Sequence 529713 from Patent EP1572962.
JD217477 - Sequence 198501 from Patent EP1572962.
JD478255 - Sequence 459279 from Patent EP1572962.
JD461724 - Sequence 442748 from Patent EP1572962.
JD194801 - Sequence 175825 from Patent EP1572962.
JD537376 - Sequence 518400 from Patent EP1572962.
JD194802 - Sequence 175826 from Patent EP1572962.
JD058303 - Sequence 39327 from Patent EP1572962.
JD144130 - Sequence 125154 from Patent EP1572962.
JD230697 - Sequence 211721 from Patent EP1572962.
JD136049 - Sequence 117073 from Patent EP1572962.
JD136050 - Sequence 117074 from Patent EP1572962.
JD444836 - Sequence 425860 from Patent EP1572962.
JD431527 - Sequence 412551 from Patent EP1572962.
JD532687 - Sequence 513711 from Patent EP1572962.
JD531720 - Sequence 512744 from Patent EP1572962.
JD138362 - Sequence 119386 from Patent EP1572962.
JD176192 - Sequence 157216 from Patent EP1572962.
JD138361 - Sequence 119385 from Patent EP1572962.
JD176191 - Sequence 157215 from Patent EP1572962.
JD176190 - Sequence 157214 from Patent EP1572962.
BC016797 - Homo sapiens chromosome 7 open reading frame 19, mRNA (cDNA clone IMAGE:4070303), partial cds.
JD247065 - Sequence 228089 from Patent EP1572962.
JD212775 - Sequence 193799 from Patent EP1572962.
JD271429 - Sequence 252453 from Patent EP1572962.
JD459836 - Sequence 440860 from Patent EP1572962.
JD131536 - Sequence 112560 from Patent EP1572962.
JD198171 - Sequence 179195 from Patent EP1572962.
JD247066 - Sequence 228090 from Patent EP1572962.
JD247067 - Sequence 228091 from Patent EP1572962.
JD413476 - Sequence 394500 from Patent EP1572962.
JD247068 - Sequence 228092 from Patent EP1572962.
JD043142 - Sequence 24166 from Patent EP1572962.
JD441432 - Sequence 422456 from Patent EP1572962.
JD339118 - Sequence 320142 from Patent EP1572962.
JD117091 - Sequence 98115 from Patent EP1572962.
JD401980 - Sequence 383004 from Patent EP1572962.
JD347312 - Sequence 328336 from Patent EP1572962.
JD481174 - Sequence 462198 from Patent EP1572962.
JD185374 - Sequence 166398 from Patent EP1572962.
JD301342 - Sequence 282366 from Patent EP1572962.
JD304654 - Sequence 285678 from Patent EP1572962.
JD337376 - Sequence 318400 from Patent EP1572962.
JD510976 - Sequence 492000 from Patent EP1572962.
JD510977 - Sequence 492001 from Patent EP1572962.
JD088871 - Sequence 69895 from Patent EP1572962.
JD088872 - Sequence 69896 from Patent EP1572962.
JD069089 - Sequence 50113 from Patent EP1572962.
JD130855 - Sequence 111879 from Patent EP1572962.
JD489638 - Sequence 470662 from Patent EP1572962.
JD525344 - Sequence 506368 from Patent EP1572962.
JD080787 - Sequence 61811 from Patent EP1572962.
JD141753 - Sequence 122777 from Patent EP1572962.
JD217383 - Sequence 198407 from Patent EP1572962.
JD370194 - Sequence 351218 from Patent EP1572962.
JD167603 - Sequence 148627 from Patent EP1572962.
JD446782 - Sequence 427806 from Patent EP1572962.
JD446783 - Sequence 427807 from Patent EP1572962.
JD427262 - Sequence 408286 from Patent EP1572962.
JD462376 - Sequence 443400 from Patent EP1572962.
JD340875 - Sequence 321899 from Patent EP1572962.
JD500539 - Sequence 481563 from Patent EP1572962.
JD556432 - Sequence 537456 from Patent EP1572962.
JD522364 - Sequence 503388 from Patent EP1572962.
JD564408 - Sequence 545432 from Patent EP1572962.
JD558331 - Sequence 539355 from Patent EP1572962.
JD319542 - Sequence 300566 from Patent EP1572962.
JD319543 - Sequence 300567 from Patent EP1572962.
JD317580 - Sequence 298604 from Patent EP1572962.
JD142915 - Sequence 123939 from Patent EP1572962.
JD051344 - Sequence 32368 from Patent EP1572962.
JD047769 - Sequence 28793 from Patent EP1572962.
JD338843 - Sequence 319867 from Patent EP1572962.
JD067571 - Sequence 48595 from Patent EP1572962.
JD553871 - Sequence 534895 from Patent EP1572962.
AK128753 - Homo sapiens cDNA FLJ44818 fis, clone BRACE3045708.
JD095296 - Sequence 76320 from Patent EP1572962.
JD339950 - Sequence 320974 from Patent EP1572962.
JD072232 - Sequence 53256 from Patent EP1572962.
JD285431 - Sequence 266455 from Patent EP1572962.
JD505163 - Sequence 486187 from Patent EP1572962.
JD505164 - Sequence 486188 from Patent EP1572962.
JD365097 - Sequence 346121 from Patent EP1572962.
JD312100 - Sequence 293124 from Patent EP1572962.
JD342502 - Sequence 323526 from Patent EP1572962.
JD480600 - Sequence 461624 from Patent EP1572962.
JD410071 - Sequence 391095 from Patent EP1572962.
JD486218 - Sequence 467242 from Patent EP1572962.
JD205814 - Sequence 186838 from Patent EP1572962.
JD512998 - Sequence 494022 from Patent EP1572962.
JD408902 - Sequence 389926 from Patent EP1572962.
JD218166 - Sequence 199190 from Patent EP1572962.
JD479305 - Sequence 460329 from Patent EP1572962.
JD336183 - Sequence 317207 from Patent EP1572962.
JD465433 - Sequence 446457 from Patent EP1572962.
JD260158 - Sequence 241182 from Patent EP1572962.
JD044000 - Sequence 25024 from Patent EP1572962.
JD389687 - Sequence 370711 from Patent EP1572962.
JD219549 - Sequence 200573 from Patent EP1572962.
JD189410 - Sequence 170434 from Patent EP1572962.
JD189172 - Sequence 170196 from Patent EP1572962.
JD336496 - Sequence 317520 from Patent EP1572962.
JD359280 - Sequence 340304 from Patent EP1572962.
JD342921 - Sequence 323945 from Patent EP1572962.
JD559322 - Sequence 540346 from Patent EP1572962.
JD272130 - Sequence 253154 from Patent EP1572962.
JD284830 - Sequence 265854 from Patent EP1572962.
JD376223 - Sequence 357247 from Patent EP1572962.
JD486757 - Sequence 467781 from Patent EP1572962.
JD221303 - Sequence 202327 from Patent EP1572962.
JD283885 - Sequence 264909 from Patent EP1572962.
JD159417 - Sequence 140441 from Patent EP1572962.
JD335802 - Sequence 316826 from Patent EP1572962.
JD391775 - Sequence 372799 from Patent EP1572962.
JD046298 - Sequence 27322 from Patent EP1572962.
JD356714 - Sequence 337738 from Patent EP1572962.
JD356713 - Sequence 337737 from Patent EP1572962.
JD111505 - Sequence 92529 from Patent EP1572962.
JD223501 - Sequence 204525 from Patent EP1572962.
JD515243 - Sequence 496267 from Patent EP1572962.
JD341760 - Sequence 322784 from Patent EP1572962.
JD532451 - Sequence 513475 from Patent EP1572962.
JD286497 - Sequence 267521 from Patent EP1572962.
JD539716 - Sequence 520740 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96SN7 (Reactome details) participates in the following event(s):

R-HSA-434700 STIM1 activation of CRAC
R-HSA-434798 CRAC translocates calcium from the extracellular region to the cytosol
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-418360 Platelet calcium homeostasis
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-5578775 Ion homeostasis
R-HSA-418346 Platelet homeostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-5576891 Cardiac conduction
R-HSA-109582 Hemostasis
R-HSA-168256 Immune System
R-HSA-397014 Muscle contraction

-  Other Names for This Gene
  Alternate Gene Symbols: AK056497, C7orf19, CBCIP2, ENST00000611770.1, ENST00000611770.2, ENST00000611770.3, ENST00000611770.4, ORAI2_HUMAN, PP1729, Q6IA68, Q8WY94, Q96SN7, Q9H9Y3, TMEM142B, uc003uzj.1, uc003uzj.2, uc003uzj.3, uc003uzj.4
UCSC ID: ENST00000611770.5
RefSeq Accession: NM_032831
Protein: Q96SN7 (aka ORAI2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.