Human Gene TES (ENST00000358204.9) from GENCODE V44
Description: Homo sapiens testin LIM domain protein (TES), transcript variant 1, mRNA. (from RefSeq NM_015641) RefSeq Summary (NM_015641): Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]. Gencode Transcript: ENST00000358204.9 Gencode Gene: ENSG00000135269.18 Transcript (Including UTRs) Position: hg38 chr7:116,210,539-116,258,783 Size: 48,245 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr7:116,210,708-116,257,482 Size: 46,775 Coding Exon Count: 7
ID:TES_HUMAN DESCRIPTION: RecName: Full=Testin; AltName: Full=TESS; FUNCTION: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. SUBUNIT: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with talin, actin, alpha- actinin, GRIP1 and PXN. Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer. SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX. SIMILARITY: Belongs to the prickle / espinas / testin family. SIMILARITY: Contains 3 LIM zinc-binding domains. SIMILARITY: Contains 1 PET domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UGI8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.