Human Gene SLC35B4 (ENST00000378509.9) from GENCODE V44
Description: Homo sapiens solute carrier family 35 member B4 (SLC35B4), mRNA. (from RefSeq NM_032826) RefSeq Summary (NM_032826): Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Gencode Transcript: ENST00000378509.9 Gencode Gene: ENSG00000205060.11 Transcript (Including UTRs) Position: hg38 chr7:134,289,332-134,316,930 Size: 27,599 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr7:134,294,833-134,316,751 Size: 21,919 Coding Exon Count: 10
ID:S35B4_HUMAN DESCRIPTION: RecName: Full=UDP-xylose and UDP-N-acetylglucosamine transporter; AltName: Full=Solute carrier family 35 member B4; AltName: Full=YEA4 homolog; FUNCTION: Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. SEQUENCE CAUTION: Sequence=BAB55325.1; Type=Erroneous initiation; WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969S0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006111 regulation of gluconeogenesis GO:0008643 carbohydrate transport GO:0015783 GDP-fucose transport GO:0015790 UDP-xylose transport GO:0055085 transmembrane transport GO:1990569 UDP-N-acetylglucosamine transmembrane transport
AK027726 - Homo sapiens cDNA FLJ14820 fis, clone OVARC1000335. AK056475 - Homo sapiens cDNA FLJ31913 fis, clone NT2RP7004790. AB052892 - Homo sapiens mRNA, similar to Yeast Yea4p, complete cds. AK075368 - Homo sapiens cDNA PSEC0055 fis, clone NT2RP2000557, highly similar to Solute carrier family 35, member B4. JD366886 - Sequence 347910 from Patent EP1572962. JD197121 - Sequence 178145 from Patent EP1572962. JD538643 - Sequence 519667 from Patent EP1572962. JD230983 - Sequence 212007 from Patent EP1572962. JD144179 - Sequence 125203 from Patent EP1572962. JD257761 - Sequence 238785 from Patent EP1572962. JD227938 - Sequence 208962 from Patent EP1572962. JD487931 - Sequence 468955 from Patent EP1572962. JD078756 - Sequence 59780 from Patent EP1572962. JD446571 - Sequence 427595 from Patent EP1572962. JD266365 - Sequence 247389 from Patent EP1572962. JD233986 - Sequence 215010 from Patent EP1572962. JD046139 - Sequence 27163 from Patent EP1572962. JD055148 - Sequence 36172 from Patent EP1572962. JD306272 - Sequence 287296 from Patent EP1572962. JD169590 - Sequence 150614 from Patent EP1572962. JD529361 - Sequence 510385 from Patent EP1572962. JD557442 - Sequence 538466 from Patent EP1572962. JD430286 - Sequence 411310 from Patent EP1572962. JD084393 - Sequence 65417 from Patent EP1572962. JD426668 - Sequence 407692 from Patent EP1572962. JD083835 - Sequence 64859 from Patent EP1572962. JD411998 - Sequence 393022 from Patent EP1572962. JD417727 - Sequence 398751 from Patent EP1572962. JD376792 - Sequence 357816 from Patent EP1572962. JD511439 - Sequence 492463 from Patent EP1572962. JD286577 - Sequence 267601 from Patent EP1572962. JD533706 - Sequence 514730 from Patent EP1572962. JD266570 - Sequence 247594 from Patent EP1572962. JD422063 - Sequence 403087 from Patent EP1572962. JD180300 - Sequence 161324 from Patent EP1572962. JD432641 - Sequence 413665 from Patent EP1572962. JD238295 - Sequence 219319 from Patent EP1572962. JD512743 - Sequence 493767 from Patent EP1572962. JD412778 - Sequence 393802 from Patent EP1572962. JD197803 - Sequence 178827 from Patent EP1572962. JD212409 - Sequence 193433 from Patent EP1572962. JD302464 - Sequence 283488 from Patent EP1572962. AK222874 - Homo sapiens mRNA for solute carrier family 35, member B4 variant, clone: HEP13336. AJ315497 - Homo sapiens mRNA for YEA4 protein (YEA4 gene). JD390816 - Sequence 371840 from Patent EP1572962. JD375076 - Sequence 356100 from Patent EP1572962. JD370723 - Sequence 351747 from Patent EP1572962. AK307621 - Homo sapiens cDNA, FLJ97569. AK027603 - Homo sapiens cDNA FLJ14697 fis, clone NT2RP2005812. BC008413 - Homo sapiens solute carrier family 35, member B4, mRNA (cDNA clone MGC:14552 IMAGE:4333393), complete cds. JD174411 - Sequence 155435 from Patent EP1572962. JD229286 - Sequence 210310 from Patent EP1572962. JD496116 - Sequence 477140 from Patent EP1572962. AJ971941 - Homo sapiens mRNA for UDP-Xylose/N-Acetylglucosamine transporter (SLC25B4 gene). KJ899843 - Synthetic construct Homo sapiens clone ccsbBroadEn_09237 SLC35B4 gene, encodes complete protein. DQ577097 - Homo sapiens piRNA piR-45209, complete sequence. AJ315498 - Homo sapiens mRNA for YEA4S protein (YEA4S gene). JD336796 - Sequence 317820 from Patent EP1572962. JD440641 - Sequence 421665 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q969S0 (Reactome details) participates in the following event(s):
R-HSA-742373 SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen R-HSA-742354 SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen R-HSA-727802 Metabolism of sugars R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules