Human Gene SLC35B4 (ENST00000378509.9) from GENCODE V44
  Description: Homo sapiens solute carrier family 35 member B4 (SLC35B4), mRNA. (from RefSeq NM_032826)
RefSeq Summary (NM_032826): Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
Gencode Transcript: ENST00000378509.9
Gencode Gene: ENSG00000205060.11
Transcript (Including UTRs)
   Position: hg38 chr7:134,289,332-134,316,930 Size: 27,599 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr7:134,294,833-134,316,751 Size: 21,919 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:134,289,332-134,316,930)mRNA (may differ from genome)Protein (331 aa)
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PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S35B4_HUMAN
DESCRIPTION: RecName: Full=UDP-xylose and UDP-N-acetylglucosamine transporter; AltName: Full=Solute carrier family 35 member B4; AltName: Full=YEA4 homolog;
FUNCTION: Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
SEQUENCE CAUTION: Sequence=BAB55325.1; Type=Erroneous initiation;
WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.05 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 187.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.30179-0.449 Picture PostScript Text
3' UTR -1612.605501-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013657 - UAA

Pfam Domains:
PF08449 - UAA transporter family

ModBase Predicted Comparative 3D Structure on Q969S0
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Gene Details    Gene Details
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Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005457 GDP-fucose transmembrane transporter activity
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity
GO:0005464 UDP-xylose transmembrane transporter activity
GO:0005515 protein binding

Biological Process:
GO:0006111 regulation of gluconeogenesis
GO:0008643 carbohydrate transport
GO:0015783 GDP-fucose transport
GO:0015790 UDP-xylose transport
GO:0055085 transmembrane transport
GO:1990569 UDP-N-acetylglucosamine transmembrane transport

Cellular Component:
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0030176 integral component of endoplasmic reticulum membrane


-  Descriptions from all associated GenBank mRNAs
  AK027726 - Homo sapiens cDNA FLJ14820 fis, clone OVARC1000335.
AK056475 - Homo sapiens cDNA FLJ31913 fis, clone NT2RP7004790.
AB052892 - Homo sapiens mRNA, similar to Yeast Yea4p, complete cds.
AK075368 - Homo sapiens cDNA PSEC0055 fis, clone NT2RP2000557, highly similar to Solute carrier family 35, member B4.
JD366886 - Sequence 347910 from Patent EP1572962.
JD197121 - Sequence 178145 from Patent EP1572962.
JD538643 - Sequence 519667 from Patent EP1572962.
JD230983 - Sequence 212007 from Patent EP1572962.
JD144179 - Sequence 125203 from Patent EP1572962.
JD257761 - Sequence 238785 from Patent EP1572962.
JD227938 - Sequence 208962 from Patent EP1572962.
JD487931 - Sequence 468955 from Patent EP1572962.
JD078756 - Sequence 59780 from Patent EP1572962.
JD446571 - Sequence 427595 from Patent EP1572962.
JD266365 - Sequence 247389 from Patent EP1572962.
JD233986 - Sequence 215010 from Patent EP1572962.
JD046139 - Sequence 27163 from Patent EP1572962.
JD055148 - Sequence 36172 from Patent EP1572962.
JD306272 - Sequence 287296 from Patent EP1572962.
JD169590 - Sequence 150614 from Patent EP1572962.
JD529361 - Sequence 510385 from Patent EP1572962.
JD557442 - Sequence 538466 from Patent EP1572962.
JD430286 - Sequence 411310 from Patent EP1572962.
JD084393 - Sequence 65417 from Patent EP1572962.
JD426668 - Sequence 407692 from Patent EP1572962.
JD083835 - Sequence 64859 from Patent EP1572962.
JD411998 - Sequence 393022 from Patent EP1572962.
JD417727 - Sequence 398751 from Patent EP1572962.
JD376792 - Sequence 357816 from Patent EP1572962.
JD511439 - Sequence 492463 from Patent EP1572962.
JD286577 - Sequence 267601 from Patent EP1572962.
JD533706 - Sequence 514730 from Patent EP1572962.
JD266570 - Sequence 247594 from Patent EP1572962.
JD422063 - Sequence 403087 from Patent EP1572962.
JD180300 - Sequence 161324 from Patent EP1572962.
JD432641 - Sequence 413665 from Patent EP1572962.
JD238295 - Sequence 219319 from Patent EP1572962.
JD512743 - Sequence 493767 from Patent EP1572962.
JD412778 - Sequence 393802 from Patent EP1572962.
JD197803 - Sequence 178827 from Patent EP1572962.
JD212409 - Sequence 193433 from Patent EP1572962.
JD302464 - Sequence 283488 from Patent EP1572962.
AK222874 - Homo sapiens mRNA for solute carrier family 35, member B4 variant, clone: HEP13336.
AJ315497 - Homo sapiens mRNA for YEA4 protein (YEA4 gene).
JD390816 - Sequence 371840 from Patent EP1572962.
JD375076 - Sequence 356100 from Patent EP1572962.
JD370723 - Sequence 351747 from Patent EP1572962.
AK307621 - Homo sapiens cDNA, FLJ97569.
AK027603 - Homo sapiens cDNA FLJ14697 fis, clone NT2RP2005812.
BC008413 - Homo sapiens solute carrier family 35, member B4, mRNA (cDNA clone MGC:14552 IMAGE:4333393), complete cds.
JD174411 - Sequence 155435 from Patent EP1572962.
JD229286 - Sequence 210310 from Patent EP1572962.
JD496116 - Sequence 477140 from Patent EP1572962.
AJ971941 - Homo sapiens mRNA for UDP-Xylose/N-Acetylglucosamine transporter (SLC25B4 gene).
KJ899843 - Synthetic construct Homo sapiens clone ccsbBroadEn_09237 SLC35B4 gene, encodes complete protein.
DQ577097 - Homo sapiens piRNA piR-45209, complete sequence.
AJ315498 - Homo sapiens mRNA for YEA4S protein (YEA4S gene).
JD336796 - Sequence 317820 from Patent EP1572962.
JD440641 - Sequence 421665 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q969S0 (Reactome details) participates in the following event(s):

R-HSA-742373 SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen
R-HSA-742354 SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen
R-HSA-727802 Metabolism of sugars
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: A4D1P3, A6NNS4, ENST00000378509.1, ENST00000378509.2, ENST00000378509.3, ENST00000378509.4, ENST00000378509.5, ENST00000378509.6, ENST00000378509.7, ENST00000378509.8, NM_032826, PSEC0055, Q53GQ7, Q8TCU7, Q969S0, Q96K33, S35B4_HUMAN, uc003vrn.1, uc003vrn.2, uc003vrn.3, uc003vrn.4, uc003vrn.5, YEA4
UCSC ID: ENST00000378509.9
RefSeq Accession: NM_032826
Protein: Q969S0 (aka S35B4_HUMAN)
CCDS: CCDS34756.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.