Human Gene RARRES2 (ENST00000223271.8) from GENCODE V44
Description: Homo sapiens retinoic acid receptor responder 2 (RARRES2), mRNA. (from RefSeq NM_002889) RefSeq Summary (NM_002889): This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]. Gencode Transcript: ENST00000223271.8 Gencode Gene: ENSG00000106538.10 Transcript (Including UTRs) Position: hg38 chr7:150,338,329-150,341,629 Size: 3,301 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr7:150,338,625-150,340,609 Size: 1,985 Coding Exon Count: 4
ID:RARR2_HUMAN DESCRIPTION: RecName: Full=Retinoic acid receptor responder protein 2; AltName: Full=RAR-responsive protein TIG2; AltName: Full=Tazarotene-induced gene 2 protein; Flags: Precursor; SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Also found in pancreas, liver, spleen, prostate, ovary, small intestine and colon. INDUCTION: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q99969
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.