Human Gene FASTK (ENST00000297532.11) from GENCODE V44
Description: Homo sapiens Fas activated serine/threonine kinase (FASTK), transcript variant 1, mRNA. (from RefSeq NM_006712) RefSeq Summary (NM_006712): The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000297532.11 Gencode Gene: ENSG00000164896.21 Transcript (Including UTRs) Position: hg38 chr7:151,076,624-151,080,809 Size: 4,186 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr7:151,076,725-151,080,766 Size: 4,042 Coding Exon Count: 10
ID:FASTK_HUMAN DESCRIPTION: RecName: Full=Fas-activated serine/threonine kinase; Short=FAST kinase; EC=2.7.11.8; FUNCTION: Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. CATALYTIC ACTIVITY: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]. SUBUNIT: Interacts with TIA-1 and TIAR. TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. PTM: Autophosphorylated on serine/threonine residues. Activated by dephosphorylation. SIMILARITY: Belongs to the FAST protein kinase family. SIMILARITY: Contains 1 RAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06743 - FAST kinase-like protein, subdomain 1 PF08368 - FAST kinase-like protein, subdomain 2 PF08373 - RAP domain
ModBase Predicted Comparative 3D Structure on Q14296
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
