Human Gene SOX7 (ENST00000304501.2) from GENCODE V44
Description: Homo sapiens SRY-box transcription factor 7 (SOX7), mRNA. (from RefSeq NM_031439) RefSeq Summary (NM_031439): This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000304501.2 Gencode Gene: ENSG00000171056.8 Transcript (Including UTRs) Position: hg38 chr8:10,723,768-10,730,511 Size: 6,744 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr8:10,725,738-10,730,433 Size: 4,696 Coding Exon Count: 2
ID:SOX7_HUMAN DESCRIPTION: RecName: Full=Transcription factor SOX-7; FUNCTION: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'. SUBUNIT: Interacts with CTNNB1/beta-catenin; this interaction may lead to the proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm. TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. DEVELOPMENTAL STAGE: In 8 week-old embryo, expressed in brain, tongue, heart, liver, lung and vertebrae. SIMILARITY: Contains 1 HMG box DNA-binding domain. SIMILARITY: Contains 1 Sox C-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BT81
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
