Human Gene TNFRSF10B (ENST00000276431.9) from GENCODE V44
Description: Homo sapiens TNF receptor superfamily member 10b (TNFRSF10B), transcript variant 1, mRNA. (from RefSeq NM_003842) RefSeq Summary (NM_003842): The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000276431.9 Gencode Gene: ENSG00000120889.13 Transcript (Including UTRs) Position: hg38 chr8:23,020,133-23,069,031 Size: 48,899 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr8:23,022,671-23,068,894 Size: 46,224 Coding Exon Count: 9
ID:TR10B_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 10B; AltName: Full=Death receptor 5; AltName: Full=TNF-related apoptosis-inducing ligand receptor 2; Short=TRAIL receptor 2; Short=TRAIL-R2; AltName: CD_antigen=CD262; Flags: Precursor; FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. SUBUNIT: Homotrimer. Can interact with TRADD and RIPK1. INTERACTION: P50591:TNFSF10; NbExp=23; IntAct=EBI-518882, EBI-495373; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. INDUCTION: By ER stress. Regulated by p53/TP53. DISEASE: Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 3 TNFR-Cys repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14763
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
