Human Gene TNFRSF10A (ENST00000221132.8) from GENCODE V44
Description: Homo sapiens TNF receptor superfamily member 10a (TNFRSF10A), mRNA. (from RefSeq NM_003844) RefSeq Summary (NM_003844): The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000221132.8 Gencode Gene: ENSG00000104689.10 Transcript (Including UTRs) Position: hg38 chr8:23,190,452-23,225,102 Size: 34,651 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr8:23,191,694-23,225,061 Size: 33,368 Coding Exon Count: 10
ID:TR10A_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 10A; AltName: Full=Death receptor 4; AltName: Full=TNF-related apoptosis-inducing ligand receptor 1; Short=TRAIL receptor 1; Short=TRAIL-R1; AltName: CD_antigen=CD261; Flags: Precursor; FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. SUBUNIT: Can interact with TRADD and RIPK1. Interacts with ARAP1. INTERACTION: Q96P48:ARAP1; NbExp=4; IntAct=EBI-518861, EBI-710003; Q14790:CASP8; NbExp=9; IntAct=EBI-518861, EBI-78060; P50591:TNFSF10; NbExp=8; IntAct=EBI-518861, EBI-495373; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 3 TNFR-Cys repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00531 - Death domain PF00020 - TNFR/NGFR cysteine-rich region
ModBase Predicted Comparative 3D Structure on O00220
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
