Human Gene ADRA1A (ENST00000276393.8) from GENCODE V44
Description: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. (from UniProt P35348) RefSeq Summary (NM_000680): Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000276393.8 Gencode Gene: ENSG00000120907.18 Transcript (Including UTRs) Position: hg38 chr8:26,769,705-26,865,405 Size: 95,701 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr8:26,770,149-26,864,969 Size: 94,821 Coding Exon Count: 2
ID:ADA1A_HUMAN DESCRIPTION: RecName: Full=Alpha-1A adrenergic receptor; AltName: Full=Alpha-1A adrenoreceptor; Short=Alpha-1A adrenoceptor; AltName: Full=Alpha-1C adrenergic receptor; AltName: Full=Alpha-adrenergic receptor 1c; FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. SUBUNIT: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. TISSUE SPECIFICITY: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. PTM: C-terminal Ser or Thr residues may be phosphorylated (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35348
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0003084 positive regulation of systemic arterial blood pressure GO:0006915 apoptotic process GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007267 cell-cell signaling GO:0007512 adult heart development GO:0007568 aging GO:0008285 negative regulation of cell proliferation GO:0009725 response to hormone GO:0010460 positive regulation of heart rate GO:0010507 negative regulation of autophagy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0019229 regulation of vasoconstriction GO:0032230 positive regulation of synaptic transmission, GABAergic GO:0035024 negative regulation of Rho protein signal transduction GO:0035265 organ growth GO:0035556 intracellular signal transduction GO:0042493 response to drug GO:0043410 positive regulation of MAPK cascade GO:0045760 positive regulation of action potential GO:0045907 positive regulation of vasoconstriction GO:0045987 positive regulation of smooth muscle contraction GO:0055117 regulation of cardiac muscle contraction GO:0060073 micturition GO:0060402 calcium ion transport into cytosol GO:0060452 positive regulation of cardiac muscle contraction GO:0061049 cell growth involved in cardiac muscle cell development GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0090037 positive regulation of protein kinase C signaling GO:0097195 pilomotor reflex GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity