Human Gene ADRA1A (ENST00000276393.8) from GENCODE V44
  Description: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. (from UniProt P35348)
RefSeq Summary (NM_000680): Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000276393.8
Gencode Gene: ENSG00000120907.18
Transcript (Including UTRs)
   Position: hg38 chr8:26,769,705-26,865,405 Size: 95,701 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr8:26,770,149-26,864,969 Size: 94,821 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:26,769,705-26,865,405)mRNA (may differ from genome)Protein (466 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIneXtProtPubMedReactome
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ADA1A_HUMAN
DESCRIPTION: RecName: Full=Alpha-1A adrenergic receptor; AltName: Full=Alpha-1A adrenoreceptor; Short=Alpha-1A adrenoceptor; AltName: Full=Alpha-1C adrenergic receptor; AltName: Full=Alpha-adrenergic receptor 1c;
FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
SUBUNIT: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.
SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
TISSUE SPECIFICITY: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
PTM: C-terminal Ser or Thr residues may be phosphorylated (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: ADRA1A
Diseases sorted by gene-association score: horner's syndrome (14), ureter cancer (12), prostatic hypertrophy (11), ureterolithiasis (8), prostatitis (7), gilles de la tourette syndrome (5), attention deficit-hyperactivity disorder (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.44 RPKM in Liver
Total median expression: 26.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -186.90436-0.429 Picture PostScript Text
3' UTR -126.70444-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001004 - Adrene_rcpt_A1Cs
IPR002233 - Adrnrgc_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P35348
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006915 apoptotic process
GO:0006937 regulation of muscle contraction
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007512 adult heart development
GO:0007568 aging
GO:0008285 negative regulation of cell proliferation
GO:0009725 response to hormone
GO:0010460 positive regulation of heart rate
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0019229 regulation of vasoconstriction
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035265 organ growth
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043410 positive regulation of MAPK cascade
GO:0045760 positive regulation of action potential
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0055117 regulation of cardiac muscle contraction
GO:0060073 micturition
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0097195 pilomotor reflex
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  AY491775 - Homo sapiens alpha 1A adrenoceptor isoform 2b (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491776 - Homo sapiens alpha 1A adrenoceptor isoform 2c (ADRA1A) mRNA, complete cds, alternatively spliced.
D32202 - Homo sapiens mRNA for alpha 1C adrenergic receptor isoform 2, complete cds.
E11339 - Human cDNA encoding alpha 1c2 adrenaline receptor.
AY491777 - Homo sapiens alpha 1A adrenoceptor isoform 3b (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491778 - Homo sapiens alpha 1A adrenoceptor isoform 3c (ADRA1A) mRNA, complete cds, alternatively spliced.
D32201 - Homo sapiens mRNA for alpha 1C adrenergic receptor isoform 3, complete cds.
E11340 - Human cDNA encoding alpha 1c3 adrenaline receptor.
AF013261 - Homo sapiens alpha 1A adrenergic receptor isoform 4 mRNA, complete cds.
D25235 - Homo sapiens mRNA for alpha1C adrenergic receptor, complete cds.
E08988 - cDNA encoding human alpha 1c adrenergic receptor.
JD367024 - Sequence 348048 from Patent EP1572962.
JD297223 - Sequence 278247 from Patent EP1572962.
JD187496 - Sequence 168520 from Patent EP1572962.
JD114189 - Sequence 95213 from Patent EP1572962.
JD267162 - Sequence 248186 from Patent EP1572962.
JD148048 - Sequence 129072 from Patent EP1572962.
JD486440 - Sequence 467464 from Patent EP1572962.
JD173072 - Sequence 154096 from Patent EP1572962.
JD215194 - Sequence 196218 from Patent EP1572962.
AK289548 - Homo sapiens cDNA FLJ77251 complete cds, highly similar to Homo sapiens adrenergic, alpha-1A-, receptor (ADRA1A), transcript variant 1, mRNA.
JD141315 - Sequence 122339 from Patent EP1572962.
U02569 - Human alpha1C adrenergic receptor mRNA, complete cds.
JD365575 - Sequence 346599 from Patent EP1572962.
JD054362 - Sequence 35386 from Patent EP1572962.
E08989 - cDNA encoding human alpha 1c adrenergic receptor.
JD080096 - Sequence 61120 from Patent EP1572962.
BC095512 - Homo sapiens adrenergic, alpha-1A-, receptor, mRNA (cDNA clone MGC:111726 IMAGE:6971913), complete cds.
L31774 - Human alpha-1C-adrenergic receptor mRNA, complete cds.
AF395806 - Homo sapiens adrenergic receptor alpha-1a (ADRA1A) mRNA, complete cds.
S76001 - alpha 1c-adrenoceptor subtype [human, brain, mRNA Partial, 432 nt].
AY491781 - Homo sapiens alpha 1A adrenoceptor isoform 6 (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491780 - Homo sapiens alpha 1A adrenoceptor isoform 5b (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491779 - Homo sapiens alpha 1A adrenoceptor isoform 5a (ADRA1A) mRNA, complete cds, alternatively spliced.
AK311558 - Homo sapiens cDNA, FLJ18600.
JD108786 - Sequence 89810 from Patent EP1572962.
JD099863 - Sequence 80887 from Patent EP1572962.
JD525952 - Sequence 506976 from Patent EP1572962.
JD358497 - Sequence 339521 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction
hsa04270 - Vascular smooth muscle contraction

Reactome (by CSHL, EBI, and GO)

Protein P35348 (Reactome details) participates in the following event(s):

R-HSA-390641 Alpha-1 adrenoceptors bind catecholamines
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13
R-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0I3, ADA1A_HUMAN, ADRA1C, B0ZBD1, B0ZBD2, B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, D25235, ENST00000276393.1, ENST00000276393.2, ENST00000276393.3, ENST00000276393.4, ENST00000276393.5, ENST00000276393.6, ENST00000276393.7, O60451, P35348, Q13675, Q13729, Q4VBM7, Q6RUJ4, Q6RUJ5, Q6RUJ7, Q6RUJ8, Q6RUJ9, Q96RE8, Q9UD63, Q9UD67, uc003xfh.1
UCSC ID: ENST00000276393.8
RefSeq Accession: NM_000680
Protein: P35348 (aka ADA1A_HUMAN or A1AA_HUMAN)
CCDS: CCDS6054.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.