Human Gene ADRA1A (ENST00000276393.8) from GENCODE V44
  Description: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. (from UniProt P35348)
RefSeq Summary (NM_000680): Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000276393.8
Gencode Gene: ENSG00000120907.18
Transcript (Including UTRs)
   Position: hg38 chr8:26,769,705-26,865,405 Size: 95,701 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr8:26,770,149-26,864,969 Size: 94,821 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:26,769,705-26,865,405)mRNA (may differ from genome)Protein (466 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Alpha-1A adrenergic receptor; AltName: Full=Alpha-1A adrenoreceptor; Short=Alpha-1A adrenoceptor; AltName: Full=Alpha-1C adrenergic receptor; AltName: Full=Alpha-adrenergic receptor 1c;
FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
SUBUNIT: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.
SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
TISSUE SPECIFICITY: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
PTM: C-terminal Ser or Thr residues may be phosphorylated (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

-  Primer design for this transcript

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-  MalaCards Disease Associations
  MalaCards Gene Search: ADRA1A
Diseases sorted by gene-association score: horner's syndrome (14), ureter cancer (12), prostatic hypertrophy (11), ureterolithiasis (8), prostatitis (7), gilles de la tourette syndrome (5), attention deficit-hyperactivity disorder (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.44 RPKM in Liver
Total median expression: 26.52 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -186.90436-0.429 Picture PostScript Text
3' UTR -126.70444-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001004 - Adrene_rcpt_A1Cs
IPR002233 - Adrnrgc_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P35348
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006915 apoptotic process
GO:0006937 regulation of muscle contraction
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007512 adult heart development
GO:0007568 aging
GO:0008285 negative regulation of cell proliferation
GO:0009725 response to hormone
GO:0010460 positive regulation of heart rate
GO:0010507 negative regulation of autophagy
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0019229 regulation of vasoconstriction
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035265 organ growth
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043410 positive regulation of MAPK cascade
GO:0045760 positive regulation of action potential
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0055117 regulation of cardiac muscle contraction
GO:0060073 micturition
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0097195 pilomotor reflex
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031965 nuclear membrane

-  Descriptions from all associated GenBank mRNAs
  AY491775 - Homo sapiens alpha 1A adrenoceptor isoform 2b (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491776 - Homo sapiens alpha 1A adrenoceptor isoform 2c (ADRA1A) mRNA, complete cds, alternatively spliced.
D32202 - Homo sapiens mRNA for alpha 1C adrenergic receptor isoform 2, complete cds.
E11339 - Human cDNA encoding alpha 1c2 adrenaline receptor.
AY491777 - Homo sapiens alpha 1A adrenoceptor isoform 3b (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491778 - Homo sapiens alpha 1A adrenoceptor isoform 3c (ADRA1A) mRNA, complete cds, alternatively spliced.
D32201 - Homo sapiens mRNA for alpha 1C adrenergic receptor isoform 3, complete cds.
E11340 - Human cDNA encoding alpha 1c3 adrenaline receptor.
AF013261 - Homo sapiens alpha 1A adrenergic receptor isoform 4 mRNA, complete cds.
D25235 - Homo sapiens mRNA for alpha1C adrenergic receptor, complete cds.
E08988 - cDNA encoding human alpha 1c adrenergic receptor.
JD367024 - Sequence 348048 from Patent EP1572962.
JD297223 - Sequence 278247 from Patent EP1572962.
JD187496 - Sequence 168520 from Patent EP1572962.
JD114189 - Sequence 95213 from Patent EP1572962.
JD267162 - Sequence 248186 from Patent EP1572962.
JD148048 - Sequence 129072 from Patent EP1572962.
JD486440 - Sequence 467464 from Patent EP1572962.
JD173072 - Sequence 154096 from Patent EP1572962.
JD215194 - Sequence 196218 from Patent EP1572962.
AK289548 - Homo sapiens cDNA FLJ77251 complete cds, highly similar to Homo sapiens adrenergic, alpha-1A-, receptor (ADRA1A), transcript variant 1, mRNA.
JD141315 - Sequence 122339 from Patent EP1572962.
U02569 - Human alpha1C adrenergic receptor mRNA, complete cds.
JD365575 - Sequence 346599 from Patent EP1572962.
JD054362 - Sequence 35386 from Patent EP1572962.
E08989 - cDNA encoding human alpha 1c adrenergic receptor.
JD080096 - Sequence 61120 from Patent EP1572962.
BC095512 - Homo sapiens adrenergic, alpha-1A-, receptor, mRNA (cDNA clone MGC:111726 IMAGE:6971913), complete cds.
L31774 - Human alpha-1C-adrenergic receptor mRNA, complete cds.
AF395806 - Homo sapiens adrenergic receptor alpha-1a (ADRA1A) mRNA, complete cds.
S76001 - alpha 1c-adrenoceptor subtype [human, brain, mRNA Partial, 432 nt].
AY491781 - Homo sapiens alpha 1A adrenoceptor isoform 6 (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491780 - Homo sapiens alpha 1A adrenoceptor isoform 5b (ADRA1A) mRNA, complete cds, alternatively spliced.
AY491779 - Homo sapiens alpha 1A adrenoceptor isoform 5a (ADRA1A) mRNA, complete cds, alternatively spliced.
AK311558 - Homo sapiens cDNA, FLJ18600.
JD108786 - Sequence 89810 from Patent EP1572962.
JD099863 - Sequence 80887 from Patent EP1572962.
JD525952 - Sequence 506976 from Patent EP1572962.
JD358497 - Sequence 339521 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction
hsa04270 - Vascular smooth muscle contraction

Reactome (by CSHL, EBI, and GO)

Protein P35348 (Reactome details) participates in the following event(s):

R-HSA-390641 Alpha-1 adrenoceptors bind catecholamines
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13
R-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0I3, ADA1A_HUMAN, ADRA1C, B0ZBD1, B0ZBD2, B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, D25235, ENST00000276393.1, ENST00000276393.2, ENST00000276393.3, ENST00000276393.4, ENST00000276393.5, ENST00000276393.6, ENST00000276393.7, O60451, P35348, Q13675, Q13729, Q4VBM7, Q6RUJ4, Q6RUJ5, Q6RUJ7, Q6RUJ8, Q6RUJ9, Q96RE8, Q9UD63, Q9UD67, uc003xfh.1
UCSC ID: ENST00000276393.8
RefSeq Accession: NM_000680
Protein: P35348 (aka ADA1A_HUMAN or A1AA_HUMAN)
CCDS: CCDS6054.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.