ID:UNC5D_HUMAN DESCRIPTION: RecName: Full=Netrin receptor UNC5D; AltName: Full=Protein unc-5 homolog 4; AltName: Full=Protein unc-5 homolog D; Flags: Precursor; FUNCTION: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). SUBUNIT: Interacts with the cytoplasmic part of DCC (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). PTM: Phosphorylated on cytoplasmic tyrosine residues (By similarity). PTM: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity). SIMILARITY: Belongs to the unc-5 family. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 TSP type-1 domains. SIMILARITY: Contains 1 ZU5 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6UXZ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
