Human Gene SFRP1 (ENST00000220772.8) from GENCODE V44
Description: Homo sapiens secreted frizzled related protein 1 (SFRP1), mRNA. (from RefSeq NM_003012) RefSeq Summary (NM_003012): This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000220772.8 Gencode Gene: ENSG00000104332.12 Transcript (Including UTRs) Position: hg38 chr8:41,261,962-41,309,473 Size: 47,512 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr8:41,265,167-41,309,159 Size: 43,993 Coding Exon Count: 3
ID:SFRP1_HUMAN DESCRIPTION: RecName: Full=Secreted frizzled-related protein 1; Short=FRP-1; Short=sFRP-1; AltName: Full=Secreted apoptosis-related protein 2; Short=SARP-2; Flags: Precursor; FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. SUBUNIT: Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8 (By similarity). SUBCELLULAR LOCATION: Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding. TISSUE SPECIFICITY: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. INDUCTION: Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. DOMAIN: The FZ domain is involved in binding with Wnt ligands (By similarity). MASS SPECTROMETRY: Mass=7266.4; Method=MALDI; Range=169-210; Note=Isoform N-glycosylated on Asn-173; Source=PubMed:11741940; MISCELLANEOUS: May have therapeutic use in cardiac surgery. SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP) family. SIMILARITY: Contains 1 FZ (frizzled) domain. SIMILARITY: Contains 1 NTR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N474
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.