Human Gene OPRK1 (ENST00000265572.8) from GENCODE V44
Description: Homo sapiens opioid receptor kappa 1 (OPRK1), transcript variant 1, mRNA. (from RefSeq NM_000912) RefSeq Summary (NM_000912): This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]. Gencode Transcript: ENST00000265572.8 Gencode Gene: ENSG00000082556.14 Transcript (Including UTRs) Position: hg38 chr8:53,225,724-53,251,637 Size: 25,914 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr8:53,229,297-53,251,037 Size: 21,741 Coding Exon Count: 3
ID:OPRK_HUMAN DESCRIPTION: RecName: Full=Kappa-type opioid receptor; Short=K-OR-1; Short=KOR-1; FUNCTION: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions. SUBUNIT: Interacts with SLC9A3R1. Interacts with GABARAPL1. INTERACTION: Q9H0R8:GABARAPL1; NbExp=5; IntAct=EBI-925028, EBI-3464833; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=Kappa opioid receptor entry; URL="http://en.wikipedia.org/wiki/Kappa_opioid_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41145
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.