Human Gene TRPA1 (ENST00000262209.5) from GENCODE V44
Description: Homo sapiens transient receptor potential cation channel subfamily A member 1 (TRPA1), mRNA. (from RefSeq NM_007332) RefSeq Summary (NM_007332): The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000262209.5 Gencode Gene: ENSG00000104321.11 Transcript (Including UTRs) Position: hg38 chr8:72,021,250-72,075,584 Size: 54,335 Total Exon Count: 27 Strand: - Coding Region Position: hg38 chr8:72,022,906-72,075,409 Size: 52,504 Coding Exon Count: 27
ID:TRPA1_HUMAN DESCRIPTION: RecName: Full=Transient receptor potential cation channel subfamily A member 1; AltName: Full=Ankyrin-like with transmembrane domains protein 1; AltName: Full=Transformation-sensitive protein p120; FUNCTION: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). ENZYME REGULATION: Inhibited by ruthenium red, a potent blocker of TRPV channels (By similarity). SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. PTM: TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain (By similarity). SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. SIMILARITY: Contains 15 ANK repeats. WEB RESOURCE: Name=Protein Spotlight; Note=The power behind pain - Issue 82 of May 2007; URL="http://web.expasy.org/spotlight/back_issues/sptlt082.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00023 - Ankyrin repeat PF00520 - Ion transport protein
ModBase Predicted Comparative 3D Structure on O75762
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0007166 cell surface receptor signaling pathway GO:0009409 response to cold GO:0010033 response to organic substance GO:0014070 response to organic cyclic compound GO:0019233 sensory perception of pain GO:0034220 ion transmembrane transport GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0048265 response to pain GO:0050896 response to stimulus GO:0050955 thermoception GO:0050966 detection of mechanical stimulus involved in sensory perception of pain GO:0050968 detection of chemical stimulus involved in sensory perception of pain GO:0051209 release of sequestered calcium ion into cytosol GO:0051289 protein homotetramerization GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport