Human Gene KCNB2 (ENST00000523207.2) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel subfamily B member 2 (KCNB2), mRNA. (from RefSeq NM_004770) RefSeq Summary (NM_004770): Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000523207.2 Gencode Gene: ENSG00000182674.6 Transcript (Including UTRs) Position: hg38 chr8:72,537,225-72,938,349 Size: 401,125 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr8:72,567,735-72,938,091 Size: 370,357 Coding Exon Count: 2
ID:KCNB2_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily B member 2; AltName: Full=Voltage-gated potassium channel subunit Kv2.2; FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. SUBUNIT: Heteromultimer with KCNS1, KCNS2 and KCNS3 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. DOMAIN: The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. PTM: Phosphorylated (Potential). SIMILARITY: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily. SEQUENCE CAUTION: Sequence=AAB08433.1; Type=Frameshift; Positions=768;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF02214 - BTB/POZ domain PF03521 - Kv2 voltage-gated K+ channel
ModBase Predicted Comparative 3D Structure on Q92953
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005251 delayed rectifier potassium channel activity GO:0005267 potassium channel activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0006940 regulation of smooth muscle contraction GO:0034765 regulation of ion transmembrane transport GO:0051260 protein homooligomerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport GO:0072659 protein localization to plasma membrane