Human Gene GSDMC (ENST00000276708.9) from GENCODE V44
  Description: Homo sapiens gasdermin C (GSDMC), mRNA. (from RefSeq NM_031415)
Gencode Transcript: ENST00000276708.9
Gencode Gene: ENSG00000147697.9
Transcript (Including UTRs)
   Position: hg38 chr8:129,748,196-129,786,624 Size: 38,429 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr8:129,748,501-129,777,587 Size: 29,087 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:129,748,196-129,786,624)mRNA (may differ from genome)Protein (508 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Gasdermin-C; AltName: Full=Melanoma-derived leucine zipper-containing extranuclear factor;
TISSUE SPECIFICITY: Expressed primarily in trachea and spleen.
SIMILARITY: Belongs to the gasdermin family.
CAUTION: Despite its name, it is unclear if this protein contains a functional leucine zipper.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.79 RPKM in Esophagus - Mucosa
Total median expression: 95.76 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -189.10618-0.306 Picture PostScript Text
3' UTR -81.70305-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007677 - Gasdermin

Pfam Domains:
PF04598 - Gasdermin family

ModBase Predicted Comparative 3D Structure on Q9BYG8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process
GO:0012501 programmed cell death

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

-  Descriptions from all associated GenBank mRNAs
  BC063595 - Homo sapiens gasdermin C, mRNA (cDNA clone MGC:75457 IMAGE:4752106), complete cds.
BC035321 - Homo sapiens gasdermin C, mRNA (cDNA clone MGC:21665 IMAGE:4753282), complete cds.
AB042405 - Homo sapiens MLZE mRNA, complete cds.
KJ906252 - Synthetic construct Homo sapiens clone ccsbBroadEn_15922 GSDMC gene, encodes complete protein.
KJ899240 - Synthetic construct Homo sapiens clone ccsbBroadEn_08634 GSDMC gene, encodes complete protein.
CU687774 - Synthetic construct Homo sapiens gateway clone IMAGE:100022829 5' read MLZE mRNA.
AJ245876 - Homo sapiens mRNA for putative cytoplasmatic protein (ORF1-FL21).
JD536857 - Sequence 517881 from Patent EP1572962.
JD475371 - Sequence 456395 from Patent EP1572962.
JD277860 - Sequence 258884 from Patent EP1572962.
JD134478 - Sequence 115502 from Patent EP1572962.
JD394873 - Sequence 375897 from Patent EP1572962.
JD103377 - Sequence 84401 from Patent EP1572962.
JD504844 - Sequence 485868 from Patent EP1572962.
JD374862 - Sequence 355886 from Patent EP1572962.
JD141826 - Sequence 122850 from Patent EP1572962.
JD153621 - Sequence 134645 from Patent EP1572962.
JD428337 - Sequence 409361 from Patent EP1572962.
JD057613 - Sequence 38637 from Patent EP1572962.
JD173539 - Sequence 154563 from Patent EP1572962.
JD441668 - Sequence 422692 from Patent EP1572962.
JD297455 - Sequence 278479 from Patent EP1572962.
JD136796 - Sequence 117820 from Patent EP1572962.
JD210867 - Sequence 191891 from Patent EP1572962.
JD539091 - Sequence 520115 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000276708.1, ENST00000276708.2, ENST00000276708.3, ENST00000276708.4, ENST00000276708.5, ENST00000276708.6, ENST00000276708.7, ENST00000276708.8, GSDMC_HUMAN, MLZE, NM_031415, Q5XKF3, Q6P494, Q9BYG8, uc003ysr.1, uc003ysr.2, uc003ysr.3, uc003ysr.4
UCSC ID: ENST00000276708.9
RefSeq Accession: NM_031415
Protein: Q9BYG8 (aka GSDMC_HUMAN)
CCDS: CCDS6360.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.