Human Gene ADCY8 (ENST00000286355.10) from GENCODE V44
Description: Homo sapiens adenylate cyclase 8 (ADCY8), mRNA. (from RefSeq NM_001115) RefSeq Summary (NM_001115): Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000286355.10 Gencode Gene: ENSG00000155897.10 Transcript (Including UTRs) Position: hg38 chr8:130,780,301-131,040,909 Size: 260,609 Total Exon Count: 18 Strand: - Coding Region Position: hg38 chr8:130,780,390-131,040,333 Size: 259,944 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06327 - Domain of Unknown Function (DUF1053) PF00211 - Adenylate and Guanylate cyclase catalytic domain
ModBase Predicted Comparative 3D Structure on P40145
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.